Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake

Annenienke C. van de Ven, Romana T. Netea-Maier, Johannes W. Smit, Ron Kusters, Jos W.J. van der Stappen, Claudia J. Pronk-Admiraal, Madelon M. Buijs, Christian H.H. Schoenmakers, Stephan G.A. Koehorst, Monique J.M. de Groot, Fred C.G.J. Sweep, Ad R.M.M. Hermus, Martin den Heijer

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Abstract

Background: In populations with mild iodine deficiency, the serum level of thyrotropin (TSH) is negatively and the serum free thyroxine (FT4) is positively associated with age. An ongoing decrease of TSH and increase of FT4 can be found after iodine supplementation. The aim of this study was to investigate whether there are current differences in the relation between thyroid function and age in relation to differences in iodine intake in the past.

Methods: Eight medical laboratories in several regions of The Netherlands, which are all iodine sufficient at present but with a difference in iodine status in the past, provided the results of all TSH and FT4 measurements performed from 2006 until 2011, resulting in 330,802 TSH and 103,940 FT4 measurements.

Results: The negative association between TSH and age in the elderly is only present in areas with a historical iodine deficiency (regression coefficients [RC] −0.008, 95% confidence interval [CI] −0.009; −0.007). In the historically iodine-sufficient population, TSH shows no obvious increase or decrease with age. In both the historically iodine-sufficient and iodine-deficient populations, FT4 levels were positively associated with age in the elderly (RC 0.009, 95% CI 0.008; 0.010 and RC 0.008, 95% CI 0.007; 0.010, respectively).

Conclusions: There are differences in relation between thyroid function and age between populations with differences in iodine intake in the past, despite an adequate iodine status at present. This raises the question whether the present but also historical iodine status of a population should be taken into account when establishing the reference limits of TSH and FT4.
Original languageEnglish
Pages (from-to)629-634
JournalThyroid
Volume25
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015

Cite this

van de Ven, A. C., Netea-Maier, R. T., Smit, J. W., Kusters, R., van der Stappen, J. W. J., Pronk-Admiraal, C. J., ... den Heijer, M. (2015). Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake. Thyroid, 25(6), 629-634. https://doi.org/10.1089/thy.2014.0574
van de Ven, Annenienke C. ; Netea-Maier, Romana T. ; Smit, Johannes W. ; Kusters, Ron ; van der Stappen, Jos W.J. ; Pronk-Admiraal, Claudia J. ; Buijs, Madelon M. ; Schoenmakers, Christian H.H. ; Koehorst, Stephan G.A. ; de Groot, Monique J.M. ; Sweep, Fred C.G.J. ; Hermus, Ad R.M.M. ; den Heijer, Martin. / Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake. In: Thyroid. 2015 ; Vol. 25, No. 6. pp. 629-634.
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title = "Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake",
abstract = "Background: In populations with mild iodine deficiency, the serum level of thyrotropin (TSH) is negatively and the serum free thyroxine (FT4) is positively associated with age. An ongoing decrease of TSH and increase of FT4 can be found after iodine supplementation. The aim of this study was to investigate whether there are current differences in the relation between thyroid function and age in relation to differences in iodine intake in the past.Methods: Eight medical laboratories in several regions of The Netherlands, which are all iodine sufficient at present but with a difference in iodine status in the past, provided the results of all TSH and FT4 measurements performed from 2006 until 2011, resulting in 330,802 TSH and 103,940 FT4 measurements.Results: The negative association between TSH and age in the elderly is only present in areas with a historical iodine deficiency (regression coefficients [RC] −0.008, 95{\%} confidence interval [CI] −0.009; −0.007). In the historically iodine-sufficient population, TSH shows no obvious increase or decrease with age. In both the historically iodine-sufficient and iodine-deficient populations, FT4 levels were positively associated with age in the elderly (RC 0.009, 95{\%} CI 0.008; 0.010 and RC 0.008, 95{\%} CI 0.007; 0.010, respectively).Conclusions: There are differences in relation between thyroid function and age between populations with differences in iodine intake in the past, despite an adequate iodine status at present. This raises the question whether the present but also historical iodine status of a population should be taken into account when establishing the reference limits of TSH and FT4.",
author = "{van de Ven}, {Annenienke C.} and Netea-Maier, {Romana T.} and Smit, {Johannes W.} and Ron Kusters and {van der Stappen}, {Jos W.J.} and Pronk-Admiraal, {Claudia J.} and Buijs, {Madelon M.} and Schoenmakers, {Christian H.H.} and Koehorst, {Stephan G.A.} and {de Groot}, {Monique J.M.} and Sweep, {Fred C.G.J.} and Hermus, {Ad R.M.M.} and {den Heijer}, Martin",
year = "2015",
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van de Ven, AC, Netea-Maier, RT, Smit, JW, Kusters, R, van der Stappen, JWJ, Pronk-Admiraal, CJ, Buijs, MM, Schoenmakers, CHH, Koehorst, SGA, de Groot, MJM, Sweep, FCGJ, Hermus, ARMM & den Heijer, M 2015, 'Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake' Thyroid, vol. 25, no. 6, pp. 629-634. https://doi.org/10.1089/thy.2014.0574

Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake. / van de Ven, Annenienke C.; Netea-Maier, Romana T.; Smit, Johannes W.; Kusters, Ron; van der Stappen, Jos W.J.; Pronk-Admiraal, Claudia J.; Buijs, Madelon M.; Schoenmakers, Christian H.H.; Koehorst, Stephan G.A.; de Groot, Monique J.M.; Sweep, Fred C.G.J.; Hermus, Ad R.M.M.; den Heijer, Martin.

In: Thyroid, Vol. 25, No. 6, 01.06.2015, p. 629-634.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake

AU - van de Ven, Annenienke C.

AU - Netea-Maier, Romana T.

AU - Smit, Johannes W.

AU - Kusters, Ron

AU - van der Stappen, Jos W.J.

AU - Pronk-Admiraal, Claudia J.

AU - Buijs, Madelon M.

AU - Schoenmakers, Christian H.H.

AU - Koehorst, Stephan G.A.

AU - de Groot, Monique J.M.

AU - Sweep, Fred C.G.J.

AU - Hermus, Ad R.M.M.

AU - den Heijer, Martin

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Background: In populations with mild iodine deficiency, the serum level of thyrotropin (TSH) is negatively and the serum free thyroxine (FT4) is positively associated with age. An ongoing decrease of TSH and increase of FT4 can be found after iodine supplementation. The aim of this study was to investigate whether there are current differences in the relation between thyroid function and age in relation to differences in iodine intake in the past.Methods: Eight medical laboratories in several regions of The Netherlands, which are all iodine sufficient at present but with a difference in iodine status in the past, provided the results of all TSH and FT4 measurements performed from 2006 until 2011, resulting in 330,802 TSH and 103,940 FT4 measurements.Results: The negative association between TSH and age in the elderly is only present in areas with a historical iodine deficiency (regression coefficients [RC] −0.008, 95% confidence interval [CI] −0.009; −0.007). In the historically iodine-sufficient population, TSH shows no obvious increase or decrease with age. In both the historically iodine-sufficient and iodine-deficient populations, FT4 levels were positively associated with age in the elderly (RC 0.009, 95% CI 0.008; 0.010 and RC 0.008, 95% CI 0.007; 0.010, respectively).Conclusions: There are differences in relation between thyroid function and age between populations with differences in iodine intake in the past, despite an adequate iodine status at present. This raises the question whether the present but also historical iodine status of a population should be taken into account when establishing the reference limits of TSH and FT4.

AB - Background: In populations with mild iodine deficiency, the serum level of thyrotropin (TSH) is negatively and the serum free thyroxine (FT4) is positively associated with age. An ongoing decrease of TSH and increase of FT4 can be found after iodine supplementation. The aim of this study was to investigate whether there are current differences in the relation between thyroid function and age in relation to differences in iodine intake in the past.Methods: Eight medical laboratories in several regions of The Netherlands, which are all iodine sufficient at present but with a difference in iodine status in the past, provided the results of all TSH and FT4 measurements performed from 2006 until 2011, resulting in 330,802 TSH and 103,940 FT4 measurements.Results: The negative association between TSH and age in the elderly is only present in areas with a historical iodine deficiency (regression coefficients [RC] −0.008, 95% confidence interval [CI] −0.009; −0.007). In the historically iodine-sufficient population, TSH shows no obvious increase or decrease with age. In both the historically iodine-sufficient and iodine-deficient populations, FT4 levels were positively associated with age in the elderly (RC 0.009, 95% CI 0.008; 0.010 and RC 0.008, 95% CI 0.007; 0.010, respectively).Conclusions: There are differences in relation between thyroid function and age between populations with differences in iodine intake in the past, despite an adequate iodine status at present. This raises the question whether the present but also historical iodine status of a population should be taken into account when establishing the reference limits of TSH and FT4.

U2 - 10.1089/thy.2014.0574

DO - 10.1089/thy.2014.0574

M3 - Article

VL - 25

SP - 629

EP - 634

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 6

ER -

van de Ven AC, Netea-Maier RT, Smit JW, Kusters R, van der Stappen JWJ, Pronk-Admiraal CJ et al. Thyrotropin Versus Age Relation as an Indicator of Historical Iodine Intake. Thyroid. 2015 Jun 1;25(6):629-634. https://doi.org/10.1089/thy.2014.0574