Time-course of depressive symptoms in patients with heart failure

Peter Johansson, Ivonne Lesman-Leegte, Johan Lundgren, Hans L. Hillege, Arno Hoes, Robbert Sanderman, Dirk J. van Veldhuisen, Tiny Jaarsma

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background It is unclear how depressive symptoms in patients with heart failure develop over time and whether this trajectory of depressive symptoms is associated with hospital admission and prognosis. Aim To describe the time-course of depressive symptoms and determine the relationship with hospitalisation and mortality. Method Data was analysed using 611 patients with completed CES-D questionnaires at baseline and at 18 months. Data on hospitalisation was collected 18 months after discharge and data on mortality was collected 18 and 36 months post-discharge. Results A total of 140 (61%) of the 229 patients with depressive symptoms at discharge had recovered from depressive symptoms after 18 months whereas 71 (18%) of the 382 non-depressed developed depressive symptoms and 89 (39%) of the 229 depressed remained depressed. Patients with recently (i.e. during the last 18 months) developed depressive symptoms showed a significantly higher risk for cardiovascular hospitalisation (HR 1.7, 95% CI 1.1–2.6, P = .016). After 36 months, patients with developed depressive symptoms after discharge were at a higher risk of all-cause mortality (HR 2.0, 95% CI 1.2–3.5, P = .012) and there was a trend towards a higher risk of all-cause mortality in patients with ongoing depressive symptoms (HR 1.7, 95% CI 0.98–3.1, P = .056). Conclusion A significant proportion of patients with HF, who were reported depressive symptoms at discharge recovered from depressive symptoms during the following 18 months. However, patients who remained having depressive symptoms or patients who developed depressive symptoms had a worse prognosis.
Original languageEnglish
Pages (from-to)238-243
JournalJournal of psychosomatic research
Volume74
Issue number3
DOIs
Publication statusPublished - 2013

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Heart Failure
Depression
Hospitalization
Mortality

Keywords

  • METIS-304984
  • IR-91711

Cite this

Johansson, P., Lesman-Leegte, I., Lundgren, J., Hillege, H. L., Hoes, A., Sanderman, R., ... Jaarsma, T. (2013). Time-course of depressive symptoms in patients with heart failure. Journal of psychosomatic research, 74(3), 238-243. https://doi.org/10.1016/j.jpsychores.2012.09.019
Johansson, Peter ; Lesman-Leegte, Ivonne ; Lundgren, Johan ; Hillege, Hans L. ; Hoes, Arno ; Sanderman, Robbert ; van Veldhuisen, Dirk J. ; Jaarsma, Tiny. / Time-course of depressive symptoms in patients with heart failure. In: Journal of psychosomatic research. 2013 ; Vol. 74, No. 3. pp. 238-243.
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abstract = "Background It is unclear how depressive symptoms in patients with heart failure develop over time and whether this trajectory of depressive symptoms is associated with hospital admission and prognosis. Aim To describe the time-course of depressive symptoms and determine the relationship with hospitalisation and mortality. Method Data was analysed using 611 patients with completed CES-D questionnaires at baseline and at 18 months. Data on hospitalisation was collected 18 months after discharge and data on mortality was collected 18 and 36 months post-discharge. Results A total of 140 (61{\%}) of the 229 patients with depressive symptoms at discharge had recovered from depressive symptoms after 18 months whereas 71 (18{\%}) of the 382 non-depressed developed depressive symptoms and 89 (39{\%}) of the 229 depressed remained depressed. Patients with recently (i.e. during the last 18 months) developed depressive symptoms showed a significantly higher risk for cardiovascular hospitalisation (HR 1.7, 95{\%} CI 1.1–2.6, P = .016). After 36 months, patients with developed depressive symptoms after discharge were at a higher risk of all-cause mortality (HR 2.0, 95{\%} CI 1.2–3.5, P = .012) and there was a trend towards a higher risk of all-cause mortality in patients with ongoing depressive symptoms (HR 1.7, 95{\%} CI 0.98–3.1, P = .056). Conclusion A significant proportion of patients with HF, who were reported depressive symptoms at discharge recovered from depressive symptoms during the following 18 months. However, patients who remained having depressive symptoms or patients who developed depressive symptoms had a worse prognosis.",
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Johansson, P, Lesman-Leegte, I, Lundgren, J, Hillege, HL, Hoes, A, Sanderman, R, van Veldhuisen, DJ & Jaarsma, T 2013, 'Time-course of depressive symptoms in patients with heart failure' Journal of psychosomatic research, vol. 74, no. 3, pp. 238-243. https://doi.org/10.1016/j.jpsychores.2012.09.019

Time-course of depressive symptoms in patients with heart failure. / Johansson, Peter; Lesman-Leegte, Ivonne; Lundgren, Johan; Hillege, Hans L.; Hoes, Arno; Sanderman, Robbert; van Veldhuisen, Dirk J.; Jaarsma, Tiny.

In: Journal of psychosomatic research, Vol. 74, No. 3, 2013, p. 238-243.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Time-course of depressive symptoms in patients with heart failure

AU - Johansson, Peter

AU - Lesman-Leegte, Ivonne

AU - Lundgren, Johan

AU - Hillege, Hans L.

AU - Hoes, Arno

AU - Sanderman, Robbert

AU - van Veldhuisen, Dirk J.

AU - Jaarsma, Tiny

PY - 2013

Y1 - 2013

N2 - Background It is unclear how depressive symptoms in patients with heart failure develop over time and whether this trajectory of depressive symptoms is associated with hospital admission and prognosis. Aim To describe the time-course of depressive symptoms and determine the relationship with hospitalisation and mortality. Method Data was analysed using 611 patients with completed CES-D questionnaires at baseline and at 18 months. Data on hospitalisation was collected 18 months after discharge and data on mortality was collected 18 and 36 months post-discharge. Results A total of 140 (61%) of the 229 patients with depressive symptoms at discharge had recovered from depressive symptoms after 18 months whereas 71 (18%) of the 382 non-depressed developed depressive symptoms and 89 (39%) of the 229 depressed remained depressed. Patients with recently (i.e. during the last 18 months) developed depressive symptoms showed a significantly higher risk for cardiovascular hospitalisation (HR 1.7, 95% CI 1.1–2.6, P = .016). After 36 months, patients with developed depressive symptoms after discharge were at a higher risk of all-cause mortality (HR 2.0, 95% CI 1.2–3.5, P = .012) and there was a trend towards a higher risk of all-cause mortality in patients with ongoing depressive symptoms (HR 1.7, 95% CI 0.98–3.1, P = .056). Conclusion A significant proportion of patients with HF, who were reported depressive symptoms at discharge recovered from depressive symptoms during the following 18 months. However, patients who remained having depressive symptoms or patients who developed depressive symptoms had a worse prognosis.

AB - Background It is unclear how depressive symptoms in patients with heart failure develop over time and whether this trajectory of depressive symptoms is associated with hospital admission and prognosis. Aim To describe the time-course of depressive symptoms and determine the relationship with hospitalisation and mortality. Method Data was analysed using 611 patients with completed CES-D questionnaires at baseline and at 18 months. Data on hospitalisation was collected 18 months after discharge and data on mortality was collected 18 and 36 months post-discharge. Results A total of 140 (61%) of the 229 patients with depressive symptoms at discharge had recovered from depressive symptoms after 18 months whereas 71 (18%) of the 382 non-depressed developed depressive symptoms and 89 (39%) of the 229 depressed remained depressed. Patients with recently (i.e. during the last 18 months) developed depressive symptoms showed a significantly higher risk for cardiovascular hospitalisation (HR 1.7, 95% CI 1.1–2.6, P = .016). After 36 months, patients with developed depressive symptoms after discharge were at a higher risk of all-cause mortality (HR 2.0, 95% CI 1.2–3.5, P = .012) and there was a trend towards a higher risk of all-cause mortality in patients with ongoing depressive symptoms (HR 1.7, 95% CI 0.98–3.1, P = .056). Conclusion A significant proportion of patients with HF, who were reported depressive symptoms at discharge recovered from depressive symptoms during the following 18 months. However, patients who remained having depressive symptoms or patients who developed depressive symptoms had a worse prognosis.

KW - METIS-304984

KW - IR-91711

U2 - 10.1016/j.jpsychores.2012.09.019

DO - 10.1016/j.jpsychores.2012.09.019

M3 - Article

VL - 74

SP - 238

EP - 243

JO - Journal of psychosomatic research

JF - Journal of psychosomatic research

SN - 0022-3999

IS - 3

ER -

Johansson P, Lesman-Leegte I, Lundgren J, Hillege HL, Hoes A, Sanderman R et al. Time-course of depressive symptoms in patients with heart failure. Journal of psychosomatic research. 2013;74(3):238-243. https://doi.org/10.1016/j.jpsychores.2012.09.019