Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles

Valeria Garbin, Dan Cojoc, Enrico Ferrari, Enzo Di Fabrizio, Marlies Overvelde, Michel Versluis, Sander van der Meer, Nico de Jong, Detlef Lohse

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)
5 Downloads (Pure)

Abstract

Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.
Original languageEnglish
Title of host publicationOptical Trapping and Optical Micromanipulation III
EditorsKishan Dholakia, Gabriel C. Spalding
PublisherSPIE
Number of pages8
ISBN (Print)9780819464057
DOIs
Publication statusPublished - 13 Aug 2006
EventSPIE Optics + Photonics 2006 - San Diego, United States
Duration: 13 Aug 200617 Aug 2006

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume6326
ISSN (Print)0277-786X

Conference

ConferenceSPIE Optics + Photonics 2006
Country/TerritoryUnited States
CitySan Diego
Period13/08/0617/08/06

Keywords

  • 2023 OA procedure

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