Tissue ablation by Holmium-YSGG laser pulses through saline and blood

T. G. van Leeuwen; M. J. van der Veen; R. M. Verdaasdonk; C. Borst

doi:10.1117/12.44105

Tissue ablation by Holmium-YSGG laser pulses through saline and blood

T. G. van Leeuwen^*, M. J. van der Veen, R. M. Verdaasdonk, C. Borst

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › Academic › peer-review

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Abstract

The use of 2.09 μm Ho-YSGG laser pulses for intra-vascular non-contact ablation of tissue has been investigated. Therefore the transmission and the temporal shape of the laser pulse transmitted through saline was measured. Also the interaction between the laser pulses (200 μs FWHM) and saline was studied by time resolved flash photography. Finally, porcine aorta was ablated (in vitro) through either blood or saline. The lesions and adjacent tissue were examined histologically. The penetration depth (the depth for a decrease to 1/e of the transmitted energy) of the laser pulses in saline depended on the power density (0.01 to 12.4 J/mm²) and varied from 0.33 to 2.2 mm, respectively. The photography showed the development of a transparent water vapor cavity around the fiber tip (320 μm) during the laser pulse. The maximum dimensions of the cavity varied as function of the intensity. Within the vapor cavity the laser pulse was undisturbed.

Original language	English
Pages (from-to)	214-219
Number of pages	6
Journal	Proceedings of SPIE - the international society for optical engineering
Volume	1427
DOIs	https://doi.org/10.1117/12.44105
Publication status	Published - 1 Jan 1991
Externally published	Yes
Event	2nd Laser-Tissue Interaction Conference 1991 - Los Angeles, United States Duration: 21 Jan 1991 → 23 Jan 1991 Conference number: 2

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title = "Tissue ablation by Holmium-YSGG laser pulses through saline and blood",

abstract = "The use of 2.09 μm Ho-YSGG laser pulses for intra-vascular non-contact ablation of tissue has been investigated. Therefore the transmission and the temporal shape of the laser pulse transmitted through saline was measured. Also the interaction between the laser pulses (200 μs FWHM) and saline was studied by time resolved flash photography. Finally, porcine aorta was ablated (in vitro) through either blood or saline. The lesions and adjacent tissue were examined histologically. The penetration depth (the depth for a decrease to 1/e of the transmitted energy) of the laser pulses in saline depended on the power density (0.01 to 12.4 J/mm2) and varied from 0.33 to 2.2 mm, respectively. The photography showed the development of a transparent water vapor cavity around the fiber tip (320 μm) during the laser pulse. The maximum dimensions of the cavity varied as function of the intensity. Within the vapor cavity the laser pulse was undisturbed.",

author = "{van Leeuwen}, {T. G.} and {van der Veen}, {M. J.} and Verdaasdonk, {R. M.} and C. Borst",

year = "1991",

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T1 - Tissue ablation by Holmium-YSGG laser pulses through saline and blood

AU - van Leeuwen, T. G.

AU - van der Veen, M. J.

AU - Verdaasdonk, R. M.

AU - Borst, C.

N1 - Conference code: 2

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The use of 2.09 μm Ho-YSGG laser pulses for intra-vascular non-contact ablation of tissue has been investigated. Therefore the transmission and the temporal shape of the laser pulse transmitted through saline was measured. Also the interaction between the laser pulses (200 μs FWHM) and saline was studied by time resolved flash photography. Finally, porcine aorta was ablated (in vitro) through either blood or saline. The lesions and adjacent tissue were examined histologically. The penetration depth (the depth for a decrease to 1/e of the transmitted energy) of the laser pulses in saline depended on the power density (0.01 to 12.4 J/mm2) and varied from 0.33 to 2.2 mm, respectively. The photography showed the development of a transparent water vapor cavity around the fiber tip (320 μm) during the laser pulse. The maximum dimensions of the cavity varied as function of the intensity. Within the vapor cavity the laser pulse was undisturbed.

AB - The use of 2.09 μm Ho-YSGG laser pulses for intra-vascular non-contact ablation of tissue has been investigated. Therefore the transmission and the temporal shape of the laser pulse transmitted through saline was measured. Also the interaction between the laser pulses (200 μs FWHM) and saline was studied by time resolved flash photography. Finally, porcine aorta was ablated (in vitro) through either blood or saline. The lesions and adjacent tissue were examined histologically. The penetration depth (the depth for a decrease to 1/e of the transmitted energy) of the laser pulses in saline depended on the power density (0.01 to 12.4 J/mm2) and varied from 0.33 to 2.2 mm, respectively. The photography showed the development of a transparent water vapor cavity around the fiber tip (320 μm) during the laser pulse. The maximum dimensions of the cavity varied as function of the intensity. Within the vapor cavity the laser pulse was undisturbed.

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DO - 10.1117/12.44105

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