Tissue assembly and organization: Developmental mechanisms in microfabricated tissues

Nicolas C. Rivron, Jeroen Rouwkema, Roman Truckenmüller, Marcel Karperien, Jan de Boer, Clemens van Blitterswijk

Research output: Contribution to journalArticleAcademicpeer-review

94 Citations (Scopus)

Abstract

In vitro-generated tissues hold significant promise in modern biology since they can potentially mimic physiological and pathological tissues. However, these are currently structurally and functionally of limited complexity and necessitate self-organization and recapitulation of tissue development mechanisms in vitro. Tools derived from nano- and microfabrications along with bottom-up strategies are emerging to allow the fabrication of primitive tissues structures that can remodel overtime. Subsequently, clues are accumulating to show that, beyond genetic material, both intrinsic tissue architectures and microenvironmental cues can lead to morphogenesis related mechanisms in vitro. The question arises, however, as how we may design and assemble structures prone to adequate tissue remodeling, predict and manipulate those developmental mechanisms in vitro? Systems integrating architectural, physical and molecular cues will allow more systematic investigation of basic principles of tissue morphogenesis, differentiation or maintenance and will feedback to reproduce the dynamic of tissue development in vitro and form more complex tissues.
Original languageEnglish
Pages (from-to)4851-4858
Number of pages8
JournalBiomaterials
Volume30
Issue number28
DOIs
Publication statusPublished - 2009

Fingerprint

Tissue
Morphogenesis
Cues
Microtechnology
Microfabrication
Nanotechnology
Maintenance
In Vitro Techniques
Feedback
Fabrication
Genes

Keywords

  • Microscale tissue engineering
  • IR-80086
  • Morphogenesis
  • Self organization

Cite this

Rivron, Nicolas C. ; Rouwkema, Jeroen ; Truckenmüller, Roman ; Karperien, Marcel ; de Boer, Jan ; van Blitterswijk, Clemens. / Tissue assembly and organization : Developmental mechanisms in microfabricated tissues. In: Biomaterials. 2009 ; Vol. 30, No. 28. pp. 4851-4858.
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Tissue assembly and organization : Developmental mechanisms in microfabricated tissues. / Rivron, Nicolas C.; Rouwkema, Jeroen; Truckenmüller, Roman; Karperien, Marcel; de Boer, Jan; van Blitterswijk, Clemens.

In: Biomaterials, Vol. 30, No. 28, 2009, p. 4851-4858.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Tissue assembly and organization

T2 - Developmental mechanisms in microfabricated tissues

AU - Rivron, Nicolas C.

AU - Rouwkema, Jeroen

AU - Truckenmüller, Roman

AU - Karperien, Marcel

AU - de Boer, Jan

AU - van Blitterswijk, Clemens

PY - 2009

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AB - In vitro-generated tissues hold significant promise in modern biology since they can potentially mimic physiological and pathological tissues. However, these are currently structurally and functionally of limited complexity and necessitate self-organization and recapitulation of tissue development mechanisms in vitro. Tools derived from nano- and microfabrications along with bottom-up strategies are emerging to allow the fabrication of primitive tissues structures that can remodel overtime. Subsequently, clues are accumulating to show that, beyond genetic material, both intrinsic tissue architectures and microenvironmental cues can lead to morphogenesis related mechanisms in vitro. The question arises, however, as how we may design and assemble structures prone to adequate tissue remodeling, predict and manipulate those developmental mechanisms in vitro? Systems integrating architectural, physical and molecular cues will allow more systematic investigation of basic principles of tissue morphogenesis, differentiation or maintenance and will feedback to reproduce the dynamic of tissue development in vitro and form more complex tissues.

KW - Microscale tissue engineering

KW - IR-80086

KW - Morphogenesis

KW - Self organization

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DO - 10.1016/j.biomaterials.2009.06.037

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