Tissue compatibility of poly(hydroxypropylglutamate)-prazosin conjugates

Xiaoling Li, Sung Wan Kim, Jan Feijen, Kazuhiro Yamaguchi, James M. Anderson

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Abstract

Biocompatibility of an injectable biodegradable drug delivery system for prazosin was investigated in Sprague-Dawley rats by histological studies after subcutaneous injection ofpoly(hydroxypropyl glutamate)-prazosin (PHPG-prazosin) conjugate particles. The studies showed that (1) the acute inflammatory response to this injectable biodegradable polymeric prodrug system was mild and of only short duration, (2) the chronic inflammation was minimal to zero, (3) the fibrous capsule could be seen starting from 7 days and became more prominent at longer time periods, (4) a collagen network was formed into the injection site after 21 days, (5) the macrophages and foreign giant cells reacted to the globules of conjugate particles, and (6) no adverse reactions were identified. Focal inflammation and the formation of the fibrous capsule around the injection site were the significant histological findings in the histopathological studies. Therefore, it is concluded that the biodegradable injectable PHPG-prazosin carbamate polymeric prodrug system is tissue biocompatible.
Original languageEnglish
Pages (from-to)181-196
Number of pages16
JournalJournal of controlled release
Volume22
Issue number2
DOIs
Publication statusPublished - 1992

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