Tissue-Engineered Vascular Grafts for Small-Diameter Arterial Replacement

M.J.B. Wissink, J. Feijen

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    The human blood circulation is a closed system of conduits that carries blood from the heart to all tissues, and from these tissues back to the heart. In this system, the aorta and other, smaller arteries distribute blood from the heart to the various parts of the body. A normal artery has a tube-like structure comprising of three distinctive layers: the intima, the media and the adventitia (figure 1). The intima, the inner layer of the artery that is in contact with blood, consists of a monolayer of endothelial cells supported by an underlying connective tissue membrane. The media comprises of e.g. collagene and elastin, with a dense population of smooth muscle cells (SMCs) that are oriented perpendicular to the blood flow. The adventitia, the outer layer of the artery, is a collagenous matrix containing fibroblasts, small blood vessels and nerves.
    Original languageEnglish
    Title of host publicationPolymer Based Systems on Tissue Engineering, Replacement and Regeneration
    EditorsRui L. Reis, Daniel Cohn
    Place of PublicationDordrecht
    PublisherKluwer Academic Publishers
    Pages391-405
    ISBN (Electronic)978-94-010-0305-6
    ISBN (Print)978-1-4020-1001-9
    DOIs
    Publication statusPublished - 15 Oct 2002
    EventNATO Advanced Study Institute (ASI) on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration 2001 - Alvor, Algarve, Portugal
    Duration: 15 Oct 200125 Oct 2001

    Publication series

    NameNATO Science Series II: Mathematics, Physics and Chemistry
    PublisherKluwer Academic Publishers
    Volume86
    ISSN (Print)1568-2609

    Conference

    ConferenceNATO Advanced Study Institute (ASI) on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration 2001
    CountryPortugal
    CityAlvor, Algarve
    Period15/10/0125/10/01

    Keywords

    • Fibrin glue
    • Patency rate
    • Vascular graft
    • Vascular prosthesis
    • Peptide growth factor

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