Tissue regenerating capacity of carbodiimide-crosslinked dermal sheep collagen during repair of the abdominal wall

P. B. Van Wachem*, M. J.A. Van Luyn, L. H.H.O. Damink, P. J. Dijkstra, J. Feijen, P. Nieuwenhuis

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    46 Citations (Scopus)

    Abstract

    In future, the function of collagen-based biomaterials as temporary scaffolds for the generation of new tissue may be emphasized. In this study the function of dermal sheep collagen (DSC) crosslinked with carbodiimide (ENDSC) as repair material for abdominal wall defects in rats was compared with that of commercial hexamethylenediisocyanate-crosslinked HDSC. The results indicate that early after implantation both ENDSC and HDSC functioned well as a matrix for cellular ingrowth. However during further implantation HDSC soon degraded resulting in herniations, while ENDSC showed a delay in the degradation time of at least 20 weeks. ENDSC thereby enabled collagen new-formation and functioned as a guidance for muscle overgrowth. These results are very promising concerning the problem of the ongoing foreign body reaction with continuing risk of implant rejection observed in clinical practice with non-degradable materials.

    Original languageEnglish
    Pages (from-to)230-239
    Number of pages10
    JournalInternational journal of artificial organs
    Volume17
    Issue number4
    Publication statusPublished - 1 Jan 1994

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