Tissue regenerating capacity of carbodiimide-crosslinked dermal sheep collagen during repair of the abdominal wall

P. B. Van Wachem; M. J.A. Van Luyn; L. H.H.O. Damink; P. J. Dijkstra; J. Feijen; P. Nieuwenhuis

Tissue regenerating capacity of carbodiimide-crosslinked dermal sheep collagen during repair of the abdominal wall

P. B. Van Wachem^*, M. J.A. Van Luyn, L. H.H.O. Damink, P. J. Dijkstra, J. Feijen, P. Nieuwenhuis

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

Abstract

In future, the function of collagen-based biomaterials as temporary scaffolds for the generation of new tissue may be emphasized. In this study the function of dermal sheep collagen (DSC) crosslinked with carbodiimide (ENDSC) as repair material for abdominal wall defects in rats was compared with that of commercial hexamethylenediisocyanate-crosslinked HDSC. The results indicate that early after implantation both ENDSC and HDSC functioned well as a matrix for cellular ingrowth. However during further implantation HDSC soon degraded resulting in herniations, while ENDSC showed a delay in the degradation time of at least 20 weeks. ENDSC thereby enabled collagen new-formation and functioned as a guidance for muscle overgrowth. These results are very promising concerning the problem of the ongoing foreign body reaction with continuing risk of implant rejection observed in clinical practice with non-degradable materials.

Original language	English
Pages (from-to)	230-239
Number of pages	10
Journal	The International journal of artificial organs
Volume	17
Issue number	4
Publication status	Published - 1 Jan 1994

Cite this

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title = "Tissue regenerating capacity of carbodiimide-crosslinked dermal sheep collagen during repair of the abdominal wall",

abstract = "In future, the function of collagen-based biomaterials as temporary scaffolds for the generation of new tissue may be emphasized. In this study the function of dermal sheep collagen (DSC) crosslinked with carbodiimide (ENDSC) as repair material for abdominal wall defects in rats was compared with that of commercial hexamethylenediisocyanate-crosslinked HDSC. The results indicate that early after implantation both ENDSC and HDSC functioned well as a matrix for cellular ingrowth. However during further implantation HDSC soon degraded resulting in herniations, while ENDSC showed a delay in the degradation time of at least 20 weeks. ENDSC thereby enabled collagen new-formation and functioned as a guidance for muscle overgrowth. These results are very promising concerning the problem of the ongoing foreign body reaction with continuing risk of implant rejection observed in clinical practice with non-degradable materials.",

author = "{Van Wachem}, {P. B.} and {Van Luyn}, {M. J.A.} and Damink, {L. H.H.O.} and Dijkstra, {P. J.} and J. Feijen and P. Nieuwenhuis",

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T1 - Tissue regenerating capacity of carbodiimide-crosslinked dermal sheep collagen during repair of the abdominal wall

AU - Van Wachem, P. B.

AU - Van Luyn, M. J.A.

AU - Damink, L. H.H.O.

AU - Dijkstra, P. J.

AU - Feijen, J.

AU - Nieuwenhuis, P.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - In future, the function of collagen-based biomaterials as temporary scaffolds for the generation of new tissue may be emphasized. In this study the function of dermal sheep collagen (DSC) crosslinked with carbodiimide (ENDSC) as repair material for abdominal wall defects in rats was compared with that of commercial hexamethylenediisocyanate-crosslinked HDSC. The results indicate that early after implantation both ENDSC and HDSC functioned well as a matrix for cellular ingrowth. However during further implantation HDSC soon degraded resulting in herniations, while ENDSC showed a delay in the degradation time of at least 20 weeks. ENDSC thereby enabled collagen new-formation and functioned as a guidance for muscle overgrowth. These results are very promising concerning the problem of the ongoing foreign body reaction with continuing risk of implant rejection observed in clinical practice with non-degradable materials.

AB - In future, the function of collagen-based biomaterials as temporary scaffolds for the generation of new tissue may be emphasized. In this study the function of dermal sheep collagen (DSC) crosslinked with carbodiimide (ENDSC) as repair material for abdominal wall defects in rats was compared with that of commercial hexamethylenediisocyanate-crosslinked HDSC. The results indicate that early after implantation both ENDSC and HDSC functioned well as a matrix for cellular ingrowth. However during further implantation HDSC soon degraded resulting in herniations, while ENDSC showed a delay in the degradation time of at least 20 weeks. ENDSC thereby enabled collagen new-formation and functioned as a guidance for muscle overgrowth. These results are very promising concerning the problem of the ongoing foreign body reaction with continuing risk of implant rejection observed in clinical practice with non-degradable materials.

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Tissue regenerating capacity of carbodiimide-crosslinked dermal sheep collagen during repair of the abdominal wall

Abstract

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