Top-down-directed synchrony from medial frontal cortex to nucleus accumbens during reward anticipation

Michael X. Cohen*, Lo Bour, Mariska Mantione, Martijn Figee, Matthijs Vink, Marina A.J. Tijssen, Anne Fleur Van Rootselaar, Pepijn Van Den Munckhof, P. Richard Schuurman, Damiaan Denys

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Scopus)

Abstract

The nucleus accumbens and medial frontal cortex (MFC) are part of a loop involved in modulating behavior according to anticipated rewards. However, the precise temporal landscape of their electrophysiological interactions in humans remains unknown because it is not possible to record neural activity from the nucleus accumbens using noninvasive techniques. We recorded electrophysiological activity simultaneously from the nucleus accumbens and cortex (via surface EEG) in humans who had electrodes implanted as part of deep-brain-stimulation treatment for obsessive-compulsive disorder. Patients performed a simple reward motivation task previously shown to activate the ventral striatum. Spectral Granger causality analyses were applied to dissociate "top-down" (cortex → nucleus accumbens)- from "bottom-up" (nucleus accumbens → cortex)-directed synchronization (functional connectivity). "Top-down"-directed synchrony from cortex to nucleus accumbens was maximal over medial frontal sites and was significantly stronger when rewards were anticipated. These findings provide direct electrophysiological evidence for a role of the MFC in modulating nucleus accumbens reward-related processing and may be relevant to understanding the mechanisms of deep-brain stimulation and its beneficial effects on psychiatric conditions.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalHuman brain mapping
Volume33
Issue number1
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Keywords

  • EEG
  • Medial frontal cortex
  • Motivation
  • Nucleus accumbens
  • Obsessive compulsive disorder
  • Reward

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