Topographical functional connectivity pattern in the perisylvian language networks

Hua Dong Xiang*, Hubert M. Fonteijn, David G. Norris, Peter Hagoort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

166 Citations (Scopus)

Abstract

We performed a resting-state functional connectivity study to investigate directly the functional correlations within the perisylvian language networks by seeding from 3 subregions of Broca's complex (pars opercularis, pars triangularis, and pars orbitalis) and their right hemisphere homologues. A clear topographical functional connectivity pattern in the left middle frontal, parietal, and temporal areas was revealed for the 3 left seeds. This is the first demonstration that a functional connectivity topology can be observed in the perisylvian language networks. The results support the assumption of the functional division for phonology, syntax, and semantics of Broca's complex as proposed by the memory, unification, and control (MUC) model and indicated a topographical functional organization in the perisylvian language networks, which suggests a possible division of labor for phonological, syntactic, and semantic function in the left frontal, parietal, and temporal areas.

Original languageEnglish
Pages (from-to)549-560
Number of pages12
JournalCerebral cortex
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

Keywords

  • Broca's complex
  • Functional organization
  • Pars opercularis (BA 44)
  • Pars orbitalis (BA 47)
  • Pars triangularis (BA 45)
  • n/a OA procedure

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