Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy

M Sartori, JW Fernandez, L Modenese, CP Carty, LA Barber, K Oberhofer, J Zhang, GG Handsfield, N.S. Stott, TF Besier, D Farina, David G Lloyd

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

This position paper proposes a modeling pipeline to develop clinically relevant neuromusculoskeletal models to understand and treat complex neurological disorders. Although applicable to a variety of neurological conditions, we provide direct pipeline applicative examples in the context of cerebral palsy (CP). This paper highlights technologies in: (1) patient-specific segmental rigid body models developed from magnetic resonance imaging for use in inverse kinematics and inverse dynamics pipelines; (2) efficient population-based approaches to derive skeletal models and muscle origins/insertions that are useful for population statistics and consistent creation of continuum models; (3) continuum muscle descriptions to account for complex muscle architecture including spatially varying material properties with muscle wrapping; (4) muscle and tendon properties specific to CP; and (5) neural-based electromyography-informed methods for muscle force prediction. This represents a novel modeling pipeline that couples for the first time electromyography extracted features of disrupted neuromuscular behavior with advanced numerical methods for modeling CP-specific musculoskeletal morphology and function. The translation of such pipeline to the clinical level will provide a new class of biomarkers that objectively describe the neuromusculoskeletal determinants of pathological locomotion and complement current clinical assessment techniques, which often rely on subjective judgment.
Original languageEnglish
Article numbere1368
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume9
Issue number2
DOIs
Publication statusPublished - 2017
Externally publishedYes

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Electromyography
Cerebral Palsy
Locomotion
Muscle
Pipelines
Muscles
Population statistics
Population Characteristics
Nervous System Diseases
Inverse kinematics
Biomechanical Phenomena
Tendons
Biomarkers
Magnetic resonance
Skeletal Muscle
Magnetic Resonance Imaging
Numerical methods
Materials properties
Technology
Imaging techniques

Cite this

Sartori, M ; Fernandez, JW ; Modenese, L ; Carty, CP ; Barber, LA ; Oberhofer, K ; Zhang, J ; Handsfield, GG ; Stott, N.S. ; Besier, TF ; Farina, D ; Lloyd, David G. / Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy. In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2017 ; Vol. 9, No. 2.
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Sartori, M, Fernandez, JW, Modenese, L, Carty, CP, Barber, LA, Oberhofer, K, Zhang, J, Handsfield, GG, Stott, NS, Besier, TF, Farina, D & Lloyd, DG 2017, 'Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy' Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 9, no. 2, e1368. https://doi.org/10.1002/wsbm.1368

Toward modeling locomotion using electromyography-informed 3D models: application to cerebral palsy. / Sartori, M; Fernandez, JW; Modenese, L; Carty, CP; Barber, LA; Oberhofer, K; Zhang, J; Handsfield, GG; Stott, N.S.; Besier, TF; Farina, D; Lloyd, David G.

In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 9, No. 2, e1368, 2017.

Research output: Contribution to journalArticleAcademicpeer-review

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