Towards a computational model for stimulation of the Pedunculopontine nucleus

Marcel Antonius Johannes Lourens; Hil Gaétan Ellart Meijer; Tjitske Heida; Stephanus A. van Gils

doi:10.1186/1471-2202-10-S1-P282

Towards a computational model for stimulation of the Pedunculopontine nucleus

Marcel Antonius Johannes Lourens, Hil Gaétan Ellart Meijer, Tjitske Heida, Stephanus A. van Gils

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment [1]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus (STN) [1]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. A hypothesis is that DBS masks the pathological synchronized firing patterns of the basal ganglia that characterize the Parkinsonian state with a regularized firing pattern. It remains unclear why stimulation of PPN should be applied with low frequency in contrast to the high frequency stimulation of STN. To get a better understanding of PPN stimulation we construct a computational model for the PPN Type I neurons in a network.

Original language	Undefined
Title of host publication	Proceedings of the 18th annual computational neuroscience meeting (CNS) 2009
Place of Publication	London, United Kingdom
Publisher	BioMed Central
Pages	282-282
Number of pages	2
DOIs	https://doi.org/10.1186/1471-2202-10-S1-P282
Publication status	Published - 13 Jul 2009
Event	18th Annual Computational Neuroscience Meeting, CNS 2009 - Berlin, Germany Duration: 18 Jul 2009 → 23 Jul 2009 Conference number: 18

Publication series

Name	BMC Neuroscience
Publisher	Biomed Central Neuroscience
Number	Suppl 1
Volume	10
ISSN (Print)	1471-2202
ISSN (Electronic)	1471-2202

Conference

Conference	18th Annual Computational Neuroscience Meeting, CNS 2009
Abbreviated title	CNS
Country/Territory	Germany
City	Berlin
Period	18/07/09 → 23/07/09

Keywords

METIS-265224
EWI-15994
Neuroscience
IR-67578

Access to Document

10.1186/1471-2202-10-S1-P282

Cite this

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title = "Towards a computational model for stimulation of the Pedunculopontine nucleus",

abstract = "The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment [1]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus (STN) [1]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. A hypothesis is that DBS masks the pathological synchronized firing patterns of the basal ganglia that characterize the Parkinsonian state with a regularized firing pattern. It remains unclear why stimulation of PPN should be applied with low frequency in contrast to the high frequency stimulation of STN. To get a better understanding of PPN stimulation we construct a computational model for the PPN Type I neurons in a network.",

keywords = "METIS-265224, EWI-15994, Neuroscience, IR-67578",

author = "Lourens, {Marcel Antonius Johannes} and Meijer, {Hil Ga{\'e}tan Ellart} and Tjitske Heida and {van Gils}, {Stephanus A.}",

note = "Proceedings of the 18th Annual Computational Neuroscience Meeting (CNS) 2009, Berlin, Germany 18-23 July 2009 ; 18th Annual Computational Neuroscience Meeting, CNS 2009 ; Conference date: 18-07-2009 Through 23-07-2009",

year = "2009",

month = jul,

day = "13",

doi = "10.1186/1471-2202-10-S1-P282",

language = "Undefined",

series = "BMC Neuroscience",

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Lourens, MAJ, Meijer, HGE , Heida, T & van Gils, SA 2009, Towards a computational model for stimulation of the Pedunculopontine nucleus. in Proceedings of the 18th annual computational neuroscience meeting (CNS) 2009. BMC Neuroscience, no. Suppl 1, vol. 10, BioMed Central, London, United Kingdom, pp. 282-282, 18th Annual Computational Neuroscience Meeting, CNS 2009, Berlin, Berlin, Germany, 18/07/09. https://doi.org/10.1186/1471-2202-10-S1-P282

Towards a computational model for stimulation of the Pedunculopontine nucleus. / Lourens, Marcel Antonius Johannes; Meijer, Hil Gaétan Ellart ; Heida, Tjitske et al.
Proceedings of the 18th annual computational neuroscience meeting (CNS) 2009. London, United Kingdom: BioMed Central, 2009. p. 282-282 (BMC Neuroscience; Vol. 10, No. Suppl 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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