Towards a cultured neural probe: patterning of networks and their electrical activity

Wim Rutten, T.G. Ruardij, Enrico Marani, B.H. Roelofsen

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


    Efficient and selective electrical stimulation and recording of neural activity in peripheral, spinal, or central neural pathways require microelectrode arrays (MEAs) at micrometer of nanometer scale. At present, wire arrays in brain, flexible linear arrays in the cochlea, and cuff arrays around nerve trunks are in experimental and/or clinical use. Two- and three-dimensional brushlike microarrays and 'sieves', with around a hundred electrode sites, have been proposed, fabricated in microtechnology, and/or tested in a numer of laboratories. ...... In this chapter we report the latest progress regarding two aspects: (1) enhanced neurophilic/neurophobic contrast and (2) spontaneous and synchronized activity of patterned host islands.
    Original languageUndefined
    Title of host publicationHandbook of Neural Engineering
    EditorsM Akay
    Place of PublicationU.S.A.
    Number of pages12
    ISBN (Print)978-0-470-05669-1
    Publication statusPublished - 2007

    Publication series

    NameIEEE Press Series in Biomedical Engineering
    PublisherJohn Wiley & Sons, Inc.


    • EWI-9478
    • METIS-242058
    • BSS-Neurotechnology and cellular engineering

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