Towards acousto-optic tissue imaging with nanosecond laser pulses

S.G. Resink, E. Hondebrink, W. Steenbergen

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
116 Downloads (Pure)


We present a way to generate acousto-optical signals in timovssue-like media with nanosecond laser pulses. Our method is based on recording and analyzing speckle patterns formed by interaction of nanosecond laser pulses with tissue, without and with simultaneous application of ultrasound. Stroboscopic application allows visualizing the temporal behavior of speckles while the ultrasound is propagating through the medium. We investigate two ways of quantifying the acousto-optic effect, viz. adding and subtracting speckle patterns obtained at various ultrasound phases. Both methods are compared with the existing speckle contrast method using a 2D scan and are found to perform similarly. Our method gives outlook on overcoming the speckle decorrelation problem in acousto-optics, and therefore brings in-vivo acousto-optic measurements one step closer. Furthermore it enables combining acousto-optics and photoacoustics in one setup with a single laser.
Original languageEnglish
Pages (from-to)3564-3571
Number of pages8
JournalOptics express
Issue number3
Publication statusPublished - 2014


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