The use of spectroscopic optical coherence tomography to assess hemoglobin oxygen saturation of whole blood is investigated. We propose to use the differential attenuation coefficient to determine the degree of saturation. Our data show qualitative agreement between the measured differential attenuation coefficients as a function of saturation and predictions based on the oxygen-saturation-dependent absorption and scattering properties of blood.
Faber, D. J., Mik, E. G., Aalders, M. C. G., & van Leeuwen, T. (2005). Towards assessment of blood oxygen saturation by spectroscopic optical coherence tomography. Optics letters, 30(9), 1015-1017. https://doi.org/10.1364/OL.30.001015