TY - JOUR
T1 - Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease
AU - Derikx, L.C.
AU - Verdonschot, Nicolaas Jacobus Joseph
AU - Tanck, E.
N1 - Open access
PY - 2015
Y1 - 2015
N2 - Current clinical practice lacks an accurate predictor for the pathological fracture risk in metastatic bone disease, but biomechanical tools are under development to improve these predictions. In this paper we explain the limitations of currently used clinical guidelines and provide an overview of more objective and quantitative approaches that have been proposed for fracture risk assessment in metastatic bone disease. Currently, such mechanical models are as sensitive and specific as clinical guidelines, but there are a number of opportunities to further improve their predictive capacity. Hence, they are a promising tool to decrease the numbers of over- and undertreated patients.
AB - Current clinical practice lacks an accurate predictor for the pathological fracture risk in metastatic bone disease, but biomechanical tools are under development to improve these predictions. In this paper we explain the limitations of currently used clinical guidelines and provide an overview of more objective and quantitative approaches that have been proposed for fracture risk assessment in metastatic bone disease. Currently, such mechanical models are as sensitive and specific as clinical guidelines, but there are a number of opportunities to further improve their predictive capacity. Hence, they are a promising tool to decrease the numbers of over- and undertreated patients.
KW - IR-100885
KW - METIS-310858
U2 - 10.1016/j.jbiomech.2014.12.017
DO - 10.1016/j.jbiomech.2014.12.017
M3 - Article
SN - 0021-9290
VL - 48
SP - 761
EP - 766
JO - Journal of biomechanics
JF - Journal of biomechanics
IS - 5
ER -