Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    We show that both the post pattern and arrangement have an influence on the cell movement (zigzag vs. bump mode) in deterministic hydrodynamics while the current theory is limited to one parameter, the array row shift ε for cylindrical posts. Besides, a new mechanism of cell movement, the “stair movement��? mechanism is reported; thereby, cells are laterally shifted across stream lines in a laminar flow. Our new designs greatly shorten the separation length (~1 mm vs. ~20 cm) for fractionating cells compared to previous works [1], and consequently the separation time, and alleviate any cell clogging problem
    Original languageUndefined
    Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    EditorsL.E. Locascio, M. Gaitan, B.M. Paegel, D.J. Ross, W.N. Vreeland
    Place of PublicationSan Diego
    PublisherChemical and Biological Micro Systems Society
    Pages1236-1238
    Number of pages3
    ISBN (Print)978-0-9798064-1-4
    Publication statusPublished - 12 Oct 2008
    Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2008 - San Diego, United States
    Duration: 12 Oct 200816 Oct 2008
    Conference number: 12

    Publication series

    NameMicro Total Analysis Systems
    PublisherChemical and Biological Micro Systems Society
    Number412
    Volume2
    ISSN (Print)1556-5890

    Conference

    Conference12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2008
    Abbreviated titleMicroTAS
    CountryUnited States
    CitySan Diego
    Period12/10/0816/10/08

    Keywords

    • EWI-14982
    • IR-62719
    • METIS-255466

    Cite this

    Li, J., le Gac, S., & van den Berg, A. (2008). Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics. In L. E. Locascio, M. Gaitan, B. M. Paegel, D. J. Ross, & W. N. Vreeland (Eds.), 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1236-1238). (Micro Total Analysis Systems; Vol. 2, No. 412). San Diego: Chemical and Biological Micro Systems Society.
    Li, J. ; le Gac, Severine ; van den Berg, Albert. / Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics. 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / L.E. Locascio ; M. Gaitan ; B.M. Paegel ; D.J. Ross ; W.N. Vreeland. San Diego : Chemical and Biological Micro Systems Society, 2008. pp. 1236-1238 (Micro Total Analysis Systems; 412).
    @inproceedings{f359c3daf7b44fe58258bdea47673e22,
    title = "Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics",
    abstract = "We show that both the post pattern and arrangement have an influence on the cell movement (zigzag vs. bump mode) in deterministic hydrodynamics while the current theory is limited to one parameter, the array row shift ε for cylindrical posts. Besides, a new mechanism of cell movement, the “stair movement��? mechanism is reported; thereby, cells are laterally shifted across stream lines in a laminar flow. Our new designs greatly shorten the separation length (~1 mm vs. ~20 cm) for fractionating cells compared to previous works [1], and consequently the separation time, and alleviate any cell clogging problem",
    keywords = "EWI-14982, IR-62719, METIS-255466",
    author = "J. Li and {le Gac}, Severine and {van den Berg}, Albert",
    note = "http://eprints.ewi.utwente.nl/14982",
    year = "2008",
    month = "10",
    day = "12",
    language = "Undefined",
    isbn = "978-0-9798064-1-4",
    series = "Micro Total Analysis Systems",
    publisher = "Chemical and Biological Micro Systems Society",
    number = "412",
    pages = "1236--1238",
    editor = "L.E. Locascio and M. Gaitan and B.M. Paegel and D.J. Ross and W.N. Vreeland",
    booktitle = "12th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

    }

    Li, J, le Gac, S & van den Berg, A 2008, Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics. in LE Locascio, M Gaitan, BM Paegel, DJ Ross & WN Vreeland (eds), 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Micro Total Analysis Systems, no. 412, vol. 2, Chemical and Biological Micro Systems Society, San Diego, pp. 1236-1238, 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2008, San Diego, United States, 12/10/08.

    Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics. / Li, J.; le Gac, Severine; van den Berg, Albert.

    12th International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / L.E. Locascio; M. Gaitan; B.M. Paegel; D.J. Ross; W.N. Vreeland. San Diego : Chemical and Biological Micro Systems Society, 2008. p. 1236-1238 (Micro Total Analysis Systems; Vol. 2, No. 412).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    AU - van den Berg, Albert

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    PY - 2008/10/12

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    N2 - We show that both the post pattern and arrangement have an influence on the cell movement (zigzag vs. bump mode) in deterministic hydrodynamics while the current theory is limited to one parameter, the array row shift ε for cylindrical posts. Besides, a new mechanism of cell movement, the “stair movement��? mechanism is reported; thereby, cells are laterally shifted across stream lines in a laminar flow. Our new designs greatly shorten the separation length (~1 mm vs. ~20 cm) for fractionating cells compared to previous works [1], and consequently the separation time, and alleviate any cell clogging problem

    AB - We show that both the post pattern and arrangement have an influence on the cell movement (zigzag vs. bump mode) in deterministic hydrodynamics while the current theory is limited to one parameter, the array row shift ε for cylindrical posts. Besides, a new mechanism of cell movement, the “stair movement��? mechanism is reported; thereby, cells are laterally shifted across stream lines in a laminar flow. Our new designs greatly shorten the separation length (~1 mm vs. ~20 cm) for fractionating cells compared to previous works [1], and consequently the separation time, and alleviate any cell clogging problem

    KW - EWI-14982

    KW - IR-62719

    KW - METIS-255466

    M3 - Conference contribution

    SN - 978-0-9798064-1-4

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    BT - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences

    A2 - Locascio, L.E.

    A2 - Gaitan, M.

    A2 - Paegel, B.M.

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    A2 - Vreeland, W.N.

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    ER -

    Li J, le Gac S, van den Berg A. Towards fast plasma and blood cell separation - pattern and arrangement investigation of post arrays used in deterministic hydrodynamics. In Locascio LE, Gaitan M, Paegel BM, Ross DJ, Vreeland WN, editors, 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences. San Diego: Chemical and Biological Micro Systems Society. 2008. p. 1236-1238. (Micro Total Analysis Systems; 412).