Transdermal timolol delivery from a Pluronic gel

D. Stamatialis; H.H.M. Rolevink; G.H. Koops

doi:10.1016/j.jconrel.2006.09.046

Transdermal timolol delivery from a Pluronic gel

D. Stamatialis, H.H.M. Rolevink, G.H. Koops

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Abstract

In this work, the transdermal timolol (TM) delivery from a Pluronic F127 (PL) gel reservoir was investigated. Both gel concentration and the artificial membrane are used to regulate the TM delivery through pig stratum corneum (SC). At low PL concentrations and for high pore size membranes, the SC mainly controls the TM delivery. At high PL concentrations and for low pore size membranes, the contribution of the system (gel + artificial membrane) to the TM delivery becomes significant.

Original language	English
Pages (from-to)	e53-e55
Journal	Journal of controlled release
Volume	116
Issue number	2
DOIs	https://doi.org/10.1016/j.jconrel.2006.09.046
Publication status	Published - 2006

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title = "Transdermal timolol delivery from a Pluronic gel",

abstract = "In this work, the transdermal timolol (TM) delivery from a Pluronic F127 (PL) gel reservoir was investigated. Both gel concentration and the artificial membrane are used to regulate the TM delivery through pig stratum corneum (SC). At low PL concentrations and for high pore size membranes, the SC mainly controls the TM delivery. At high PL concentrations and for low pore size membranes, the contribution of the system (gel + artificial membrane) to the TM delivery becomes significant.",

author = "D. Stamatialis and H.H.M. Rolevink and G.H. Koops",

note = "Proceedings of the Ninth European Symposium on Controlled Drug Delivery ",

year = "2006",

doi = "10.1016/j.jconrel.2006.09.046",

language = "English",

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pages = "e53--e55",

journal = "Journal of controlled release",

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T1 - Transdermal timolol delivery from a Pluronic gel

AU - Stamatialis, D.

AU - Rolevink, H.H.M.

AU - Koops, G.H.

N1 - Proceedings of the Ninth European Symposium on Controlled Drug Delivery

PY - 2006

Y1 - 2006

N2 - In this work, the transdermal timolol (TM) delivery from a Pluronic F127 (PL) gel reservoir was investigated. Both gel concentration and the artificial membrane are used to regulate the TM delivery through pig stratum corneum (SC). At low PL concentrations and for high pore size membranes, the SC mainly controls the TM delivery. At high PL concentrations and for low pore size membranes, the contribution of the system (gel + artificial membrane) to the TM delivery becomes significant.

AB - In this work, the transdermal timolol (TM) delivery from a Pluronic F127 (PL) gel reservoir was investigated. Both gel concentration and the artificial membrane are used to regulate the TM delivery through pig stratum corneum (SC). At low PL concentrations and for high pore size membranes, the SC mainly controls the TM delivery. At high PL concentrations and for low pore size membranes, the contribution of the system (gel + artificial membrane) to the TM delivery becomes significant.

U2 - 10.1016/j.jconrel.2006.09.046

DO - 10.1016/j.jconrel.2006.09.046

M3 - Article

SN - 0168-3659

VL - 116

SP - e53-e55

JO - Journal of controlled release

JF - Journal of controlled release

IS - 2

ER -

Transdermal timolol delivery from a Pluronic gel

Abstract

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