TY - JOUR
T1 - Transdermal timolol delivery from a Pluronic gel
AU - Stamatialis, D.
AU - Rolevink, H.H.M.
AU - Koops, G.H.
N1 - Proceedings of the Ninth European Symposium on Controlled Drug Delivery
PY - 2006
Y1 - 2006
N2 - In this work, the transdermal timolol (TM) delivery from a Pluronic F127 (PL) gel reservoir was investigated. Both gel concentration and the artificial membrane are used to regulate the TM delivery through pig stratum corneum (SC). At low PL concentrations and for high pore size membranes, the SC mainly controls the TM delivery. At high PL concentrations and for low pore size membranes, the contribution of the system (gel + artificial membrane) to the TM delivery becomes significant.
AB - In this work, the transdermal timolol (TM) delivery from a Pluronic F127 (PL) gel reservoir was investigated. Both gel concentration and the artificial membrane are used to regulate the TM delivery through pig stratum corneum (SC). At low PL concentrations and for high pore size membranes, the SC mainly controls the TM delivery. At high PL concentrations and for low pore size membranes, the contribution of the system (gel + artificial membrane) to the TM delivery becomes significant.
U2 - 10.1016/j.jconrel.2006.09.046
DO - 10.1016/j.jconrel.2006.09.046
M3 - Article
SN - 0168-3659
VL - 116
SP - e53-e55
JO - Journal of controlled release
JF - Journal of controlled release
IS - 2
ER -