Transduction of selective recognition by preorganized ionophores, K$#+$# selectivity of the different 1,3-diethoxycalix[4]arene crown ether conformers

Zbigniew Brzozka, Ben Lammerink, David Reinhoudt, Eleonora Ghidini, Rocco Ungaro

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    Three different conformers of 1,3-diethoxy-p-tert-butylcalix[4]arene crown ethers have been used to study the effect of the ionophore preorganization on the potentiometric K+-selectivity. Selectivities were measured for chemically modified field effect transistors (CHEMFETs) and membrane ion-selective electrodes (ISEs) by two different methods. The ionophores show decreasing K+/Na+ selectivities in the order: partial cone > 1.3-alternate > cone. As a function of time the cone conformer maintained a constant selectivity whereas a continuous decrease of the selectivity values was observed for the other two conformers. This supports our prediction based on the association constants and our previous 1H NMR studies on conformational stability.
    Original languageUndefined
    Pages (from-to)1037-1040
    JournalJournal of the Chemical Society. Perkin transactions II
    Issue number6
    Publication statusPublished - 1993


    • IR-12564
    • METIS-106745

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