Transient Binding and Dissipation in Cross-Linked Actin Networks

O. Lieleg, Mireille Maria Anna Elisabeth Claessens, Y. Luan, A.R. Bausch

Research output: Contribution to journalArticleAcademicpeer-review

72 Citations (Scopus)
43 Downloads (Pure)

Abstract

In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events.
Original languageUndefined
Pages (from-to)108101-1-108101-4
Number of pages5
JournalPhysical review letters
Volume101
Issue number10
DOIs
Publication statusPublished - 2008

Keywords

  • IR-59955
  • METIS-250787

Cite this

Lieleg, O. ; Claessens, Mireille Maria Anna Elisabeth ; Luan, Y. ; Bausch, A.R. / Transient Binding and Dissipation in Cross-Linked Actin Networks. In: Physical review letters. 2008 ; Vol. 101, No. 10. pp. 108101-1-108101-4.
@article{ca2cbebe77e04fd79fe5b49f7317a967,
title = "Transient Binding and Dissipation in Cross-Linked Actin Networks",
abstract = "In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events.",
keywords = "IR-59955, METIS-250787",
author = "O. Lieleg and Claessens, {Mireille Maria Anna Elisabeth} and Y. Luan and A.R. Bausch",
year = "2008",
doi = "10.1103/PhysRevLett.101.108101",
language = "Undefined",
volume = "101",
pages = "108101--1--108101--4",
journal = "Physical review letters",
issn = "0031-9007",
publisher = "American Physical Society",
number = "10",

}

Transient Binding and Dissipation in Cross-Linked Actin Networks. / Lieleg, O.; Claessens, Mireille Maria Anna Elisabeth; Luan, Y.; Bausch, A.R.

In: Physical review letters, Vol. 101, No. 10, 2008, p. 108101-1-108101-4.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Transient Binding and Dissipation in Cross-Linked Actin Networks

AU - Lieleg, O.

AU - Claessens, Mireille Maria Anna Elisabeth

AU - Luan, Y.

AU - Bausch, A.R.

PY - 2008

Y1 - 2008

N2 - In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events.

AB - In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events.

KW - IR-59955

KW - METIS-250787

U2 - 10.1103/PhysRevLett.101.108101

DO - 10.1103/PhysRevLett.101.108101

M3 - Article

VL - 101

SP - 108101-1-108101-4

JO - Physical review letters

JF - Physical review letters

SN - 0031-9007

IS - 10

ER -