Abstract
Drug delivery to the brain is complicated due to the presence of the blood-brain barrier (BBB) [1]. BBB disruption has been demonstrated in vivo using ultrasound-driven microbubbles. However, the underlying mechanisms are not clear thereby limiting clinical translation [2]. Here, we aim to unravel this physical and biological multi-timescale problem by using an optically accessible BBB on-chip model, ultra-high-speed imaging of the bubble dynamics, transendothelial resistance measurements, and monodisperse microbubbles. The results show that our organ-on-chip platform together with monodisperse microbubbles is a powerful tool to correlate microbubble dynamics to the induced bioeffects.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Subtitle of host publication | 10-14 October 2021, Palm Springs, CA, USA |
| Publisher | The Chemical and Biological Microsystems Society |
| Pages | 477-478 |
| Number of pages | 2 |
| ISBN (Electronic) | 978-1-7334190-3-1 |
| Publication status | Published - 11 Oct 2021 |
| Event | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Virtual, Palm Springs, United States Duration: 10 Oct 2021 → 14 Oct 2021 |
Conference
| Conference | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 |
|---|---|
| Country/Territory | United States |
| City | Palm Springs |
| Period | 10/10/21 → 14/10/21 |
Keywords
- Blood-brain barrier
- Focused ultrasound
- Monodisperse microbubbles
- Organ-on-chip
- Sonoporation