Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles.

Mariia Zakharova; Pieter A.M. Persijn van Meerten; Martin Rolf Pieter van den Broek; Loes Segerink; Tim Joseph Segers

Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles.

Mariia Zakharova^*, Pieter A.M. Persijn van Meerten, Martin Rolf Pieter van den Broek, Loes Segerink, Tim Joseph Segers

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Drug delivery to the brain is complicated due to the presence of the blood-brain barrier (BBB) [1]. BBB disruption has been demonstrated in vivo using ultrasound-driven microbubbles. However, the underlying mechanisms are not clear thereby limiting clinical translation [2]. Here, we aim to unravel this physical and biological multi-timescale problem by using an optically accessible BBB on-chip model, ultra-high-speed imaging of the bubble dynamics, transendothelial resistance measurements, and monodisperse microbubbles. The results show that our organ-on-chip platform together with monodisperse microbubbles is a powerful tool to correlate microbubble dynamics to the induced bioeffects.

Original language	English
Title of host publication	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Subtitle of host publication	10 - 14 October 2021, Palm Springs, CA, USA
Pages	477478
Publication status	Published - 11 Oct 2021
Event	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 - Palm Springs, United States Duration: 10 Oct 2021 → 14 Oct 2021 Conference number: 25 https://microtas2021.org/

Conference

Conference	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Abbreviated title	MicroTAS 2021
Country/Territory	United States
City	Palm Springs
Period	10/10/21 → 14/10/21
Internet address	https://microtas2021.org/

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@inproceedings{e74a9c4f9acc4cfea48871e66e973e47,

title = "Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles.",

abstract = "Drug delivery to the brain is complicated due to the presence of the blood-brain barrier (BBB) [1]. BBB disruption has been demonstrated in vivo using ultrasound-driven microbubbles. However, the underlying mechanisms are not clear thereby limiting clinical translation [2]. Here, we aim to unravel this physical and biological multi-timescale problem by using an optically accessible BBB on-chip model, ultra-high-speed imaging of the bubble dynamics, transendothelial resistance measurements, and monodisperse microbubbles. The results show that our organ-on-chip platform together with monodisperse microbubbles is a powerful tool to correlate microbubble dynamics to the induced bioeffects.",

author = "Mariia Zakharova and {Persijn van Meerten}, {Pieter A.M.} and {van den Broek}, {Martin Rolf Pieter} and Loes Segerink and Segers, {Tim Joseph}",

year = "2021",

month = oct,

day = "11",

language = "English",

pages = "477478",

booktitle = "25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

note = "25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021, MicroTAS 2021 ; Conference date: 10-10-2021 Through 14-10-2021",

url = "https://microtas2021.org/",

}

Zakharova, M, Persijn van Meerten, PAM, van den Broek, MRP, Segerink, L & Segers, TJ 2021, Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles. in 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10 - 14 October 2021, Palm Springs, CA, USA. pp. 477478, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021, Palm Springs, California, United States, 10/10/21.

Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles. / Zakharova, Mariia; Persijn van Meerten, Pieter A.M.; van den Broek, Martin Rolf Pieter et al.
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences: 10 - 14 October 2021, Palm Springs, CA, USA. 2021. p. 477478.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles.

AU - Zakharova, Mariia

AU - Persijn van Meerten, Pieter A.M.

AU - van den Broek, Martin Rolf Pieter

AU - Segerink, Loes

AU - Segers, Tim Joseph

N1 - Conference code: 25

PY - 2021/10/11

Y1 - 2021/10/11

N2 - Drug delivery to the brain is complicated due to the presence of the blood-brain barrier (BBB) [1]. BBB disruption has been demonstrated in vivo using ultrasound-driven microbubbles. However, the underlying mechanisms are not clear thereby limiting clinical translation [2]. Here, we aim to unravel this physical and biological multi-timescale problem by using an optically accessible BBB on-chip model, ultra-high-speed imaging of the bubble dynamics, transendothelial resistance measurements, and monodisperse microbubbles. The results show that our organ-on-chip platform together with monodisperse microbubbles is a powerful tool to correlate microbubble dynamics to the induced bioeffects.

AB - Drug delivery to the brain is complicated due to the presence of the blood-brain barrier (BBB) [1]. BBB disruption has been demonstrated in vivo using ultrasound-driven microbubbles. However, the underlying mechanisms are not clear thereby limiting clinical translation [2]. Here, we aim to unravel this physical and biological multi-timescale problem by using an optically accessible BBB on-chip model, ultra-high-speed imaging of the bubble dynamics, transendothelial resistance measurements, and monodisperse microbubbles. The results show that our organ-on-chip platform together with monodisperse microbubbles is a powerful tool to correlate microbubble dynamics to the induced bioeffects.

M3 - Conference contribution

SP - 477478

BT - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021

Y2 - 10 October 2021 through 14 October 2021

ER -

Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles.

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