Transient disruption of a Blood-brain Barrier on-chip using focused ultrasound and monodisperse microbubbles.

Mariia Zakharova*, Pieter A.M. Persijn van Meerten, Martin Rolf Pieter van den Broek, Loes Segerink, Tim Joseph Segers

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

Drug delivery to the brain is complicated due to the presence of the blood-brain barrier (BBB) [1]. BBB disruption has been demonstrated in vivo using ultrasound-driven microbubbles. However, the underlying mechanisms are not clear thereby limiting clinical translation [2]. Here, we aim to unravel this physical and biological multi-timescale problem by using an optically accessible BBB on-chip model, ultra-high-speed imaging of the bubble dynamics, transendothelial resistance measurements, and monodisperse microbubbles. The results show that our organ-on-chip platform together with monodisperse microbubbles is a powerful tool to correlate microbubble dynamics to the induced bioeffects.
Original languageEnglish
Title of host publication25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Subtitle of host publication 10 - 14 October 2021, Palm Springs, CA, USA
Pages477478
Publication statusPublished - 11 Oct 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021 - Palm Springs, United States
Duration: 10 Oct 202114 Oct 2021
Conference number: 25
https://microtas2021.org/

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2021
Abbreviated titleMicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs
Period10/10/2114/10/21
Internet address

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