Transition metal-catalyzed functionalization of pyrazines

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Transition metal-catalyzed reactions are generally used for carbon–carbon bond formation on pyrazines and include, but are not limited to, classical palladium-catalyzed reactions like Sonogashira, Heck, Suzuki, and Stille reactions. Also a few examples of carbon–heteroatom bond formation in pyrazines are known. This perspective reviews recent progress in the field of transition metal-catalyzed cross-coupling reactions on pyrazine systems. It deals with the most important C–C- and C–X-bond formation methodologies.
Original languageEnglish
Pages (from-to)3583-3602
Number of pages20
JournalOrganic & biomolecular chemistry
Publication statusPublished - 2013


  • METIS-301583
  • IR-90129


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