Translational insight into MASH: From mechanisms to medicine

Maria Marit ten Hove

doi:10.3990/1.9789036566315

Translational insight into MASH: From mechanisms to medicine

Maria Marit ten Hove

Research output: Thesis › PhD Thesis - Research UT, graduation UT

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Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly prevalent global health issue, characterized by hepatic steatosis, inflammation, and fibrosis. MASH can progress to end-stage liver diseases, including cirrhosis, end-stage liver failure, and hepatocellular carcinoma, if not treated. Its multifaceted pathology, driven by dysregulated lipid metabolism, chronic inflammation, and fibrotic remodeling, presents significant therapeutic challenges, necessitating the development of targeted interventions that address the disease’s complexity. This thesis explores innovative and translational therapeutic strategies by dissecting key pathways driving MASH progression, by contributing to the understanding of the molecular and cellular mechanisms driving MASH progression and exploring the therapeutic potential of novel treatments by targeting steatosis, inflammation, and/or fibrosis.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Twente
Supervisors/Advisors	Bansal, R. , Supervisor Passier, P.C.J.J., Supervisor Kocer, Armagan, Supervisor
Award date	8 Jul 2025
Place of Publication	Enschede
Publisher	University of Twente
Print ISBNs	978-90-365-6630-8
Electronic ISBNs	978-90-365-6631-5
DOIs	https://doi.org/10.3990/1.9789036566315
Publication status	Published - 8 Jul 2025

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10.3990/1.9789036566315

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PhD thesis M.M. ten Hove
Final published version, 25.2 MB
Embargo ends: 16/03/26

Cite this

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abstract = "Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly prevalent global health issue, characterized by hepatic steatosis, inflammation, and fibrosis. MASH can progress to end-stage liver diseases, including cirrhosis, end-stage liver failure, and hepatocellular carcinoma, if not treated. Its multifaceted pathology, driven by dysregulated lipid metabolism, chronic inflammation, and fibrotic remodeling, presents significant therapeutic challenges, necessitating the development of targeted interventions that address the disease{\textquoteright}s complexity. This thesis explores innovative and translational therapeutic strategies by dissecting key pathways driving MASH progression, by contributing to the understanding of the molecular and cellular mechanisms driving MASH progression and exploring the therapeutic potential of novel treatments by targeting steatosis, inflammation, and/or fibrosis.",

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AB - Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly prevalent global health issue, characterized by hepatic steatosis, inflammation, and fibrosis. MASH can progress to end-stage liver diseases, including cirrhosis, end-stage liver failure, and hepatocellular carcinoma, if not treated. Its multifaceted pathology, driven by dysregulated lipid metabolism, chronic inflammation, and fibrotic remodeling, presents significant therapeutic challenges, necessitating the development of targeted interventions that address the disease’s complexity. This thesis explores innovative and translational therapeutic strategies by dissecting key pathways driving MASH progression, by contributing to the understanding of the molecular and cellular mechanisms driving MASH progression and exploring the therapeutic potential of novel treatments by targeting steatosis, inflammation, and/or fibrosis.

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M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-6630-8

PB - University of Twente

CY - Enschede

ER -

Translational insight into MASH: From mechanisms to medicine

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