Treatment and survival of patients with small-cell lung cancer: small steps forward, but not for patients >80

M.L.G. Janssen-Heijnen, H.A.A.M. Maas, Sabine Siesling, C.C.E. Koning, J.W.W. Coebergh, H.J.M. Groen

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Background: Seventy-five percent of newly diagnosed patients with small-cell lung cancer (SCLC) are aged 60+ and quite a few are treated less aggressively because of fear of toxic effects. We described trends in treatment and survival of unselected SCLC patients. Patients and methods: For the present study, all 13 007 SCLC patients aged 60+ diagnosed in The Netherlands from 1997 to 2007 were included. Results: Among patients with limited disease, the proportion receiving chemoradiation increased from 35% to almost 60% for those aged 60–69, from 28% to 48% in age group 70–74, from 17% to 33% in age group 75–79, but remained <10% for those aged 80+. Among patients with extensive disease, the proportion receiving chemotherapy (CT) decreased from 81% of patients aged 60–64 to 23% of those aged 85+, without substantial changes over time. Survival has only improved for patients <80 years. Conclusions: CT (+radiotherapy) has improved survival for unselected SCLC patients <80. A better understanding of the impact of frailty on completion of treatment and toxic effects among patients aged 80+ would enable the treating physician to anticipate toxic effects better and to discuss risks and benefits of treatment with the patient
Original languageEnglish
Pages (from-to)954-960
JournalAnnals of oncology
Volume23
Issue number4
DOIs
Publication statusPublished - 2012

Keywords

  • IR-82434
  • METIS-290287

Fingerprint Dive into the research topics of 'Treatment and survival of patients with small-cell lung cancer: small steps forward, but not for patients >80'. Together they form a unique fingerprint.

Cite this