Trends, Advantages and Disadvantages in Combined Extracorporeal Lung and Kidney Support From a Technical Point of View

Ana Martins Costa*, Frank Halfwerk, Bettina Wiegmann, Michael Neidlin, Jutta Arens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
351 Downloads (Pure)

Abstract

Extracorporeal membrane oxygenation (ECMO) provides pulmonary and/or cardiac support for critically ill patients. Due to their diseases, they are at high risk of developing acute kidney injury. In that case, continuous renal replacement therapy (CRRT) is applied to provide renal support and fluid management. The ECMO and CRRT circuits can be combined by an integrated or parallel approach. So far, all methods used for combined extracorporeal lung and kidney support present serious drawbacks. This includes not only high risks of circuit related complications such as bleeding, thrombus formation, and hemolysis, but also increase in technical workload and health care costs. In this sense, the development of a novel optimized artificial lung device with integrated renal support could offer important treatment benefits. Therefore, we conducted a review to provide technical background on existing techniques for extracorporeal lung and kidney support and give insight on important aspects to be addressed in the development of this novel highly integrated artificial lung device.
Original languageEnglish
Article number909990
JournalFrontiers in Medical Technology
Volume4
DOIs
Publication statusPublished - 21 Jun 2022

Keywords

  • Veno-venous ECMO
  • Continuous RRT
  • Extracorporeal life support (ECLS)
  • Artificial kidney
  • Artificial lung
  • Artificial organ
  • Kidney insufficiency

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