Trends in local, regional and contralateral breast tumor recurrence within five years after diagnosis in the Netherlands: A population-based study including 121347 patients

J. Meijer; H.J.G.D. van den Bongard; L.B. Koppert; C.W. Menke-van der Houven van Oordt; L. de Munck; T.J.A. van Nijnatten; M.J.C. van der Sangen; R.J. Schipper; M.K. Schmidt; M.L. Smidt; W. Vreuls; M.C. van Maaren; S. Siesling

doi:10.1016/j.breast.2025.104673

Trends in local, regional and contralateral breast tumor recurrence within five years after diagnosis in the Netherlands: A population-based study including 121347 patients

J. Meijer^*
, H.J.G.D. van den Bongard
, L.B. Koppert
, C.W. Menke-van der Houven van Oordt
, L. de Munck
, T.J.A. van Nijnatten
, M.J.C. van der Sangen
, R.J. Schipper
, M.K. Schmidt
, M.L. Smidt
, W. Vreuls
, M.C. van Maaren
, S. Siesling

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The objective was to provide an overview of trends in five-year local recurrence (LR), regional recurrence (RR) and contralateral breast cancer (CBC) rates in the Netherlands from 2003 to 2008 and 2012–2016.

Methods: Women ≥18 years diagnosed with primary early breast cancer between 2003-2008 and 2012–2016 in the Netherlands were included. LR was defined as invasive tumor on the same side as the primary breast cancer. RR was defined as regional lymph node metastasis. CBC was defined as second primary invasive breast tumor in the contralateral breast. Five-year LR, RR and CBC rates were calculated and stratified for age, stage, subtype, and grade.

Results: Of the 121347 included patients, 5618 were diagnosed with a LR, RR or CBC. Five-year LR, RR and CBC rates decreased from 3.3 %, 1.9 % and 2.2 % in 2003 to 1.5 %, 1.6 % and 1.5 % in 2016, respectively, with fluctuations over the years. Slight increases were observed in RR rates for stage II-III, HR-/HER2+ and HR-/HER2-.

Conclusion: (s). The observed overall decline in LR, RR and CBC rates could reflect more effective and personalized breast cancer treatment. Our results provide realistic insights in LR, RR and CBC rates and might contribute to further optimization of treatment and surveillance strategies.

Original language	English
Article number	104673
Number of pages	10
Journal	Breast
Volume	85
Early online date	9 Dec 2025
DOIs	https://doi.org/10.1016/j.breast.2025.104673
Publication status	Published - Feb 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

UT-Gold-D
Contralateral breast cancer
Local recurrence
Real world data
Regional recurrence
Breast cancer

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ArticleFinal published version, 1.72 MBLicence: CC BY

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Meijer, J., van den Bongard, H. J. G. D., Koppert, L. B., Menke-van der Houven van Oordt, C. W., de Munck, L., van Nijnatten, T. J. A., van der Sangen, M. J. C., Schipper, R. J., Schmidt, M. K., Smidt, M. L., Vreuls, W., van Maaren, M. C., & Siesling, S. (2026). Trends in local, regional and contralateral breast tumor recurrence within five years after diagnosis in the Netherlands: A population-based study including 121347 patients. Breast, 85, Article 104673. https://doi.org/10.1016/j.breast.2025.104673

@article{34076a7a8cfb436c91e7ca7c1193fd39,

title = "Trends in local, regional and contralateral breast tumor recurrence within five years after diagnosis in the Netherlands: A population-based study including 121347 patients",

abstract = "Background: The objective was to provide an overview of trends in five-year local recurrence (LR), regional recurrence (RR) and contralateral breast cancer (CBC) rates in the Netherlands from 2003 to 2008 and 2012–2016.Methods: Women ≥18 years diagnosed with primary early breast cancer between 2003-2008 and 2012–2016 in the Netherlands were included. LR was defined as invasive tumor on the same side as the primary breast cancer. RR was defined as regional lymph node metastasis. CBC was defined as second primary invasive breast tumor in the contralateral breast. Five-year LR, RR and CBC rates were calculated and stratified for age, stage, subtype, and grade.Results: Of the 121347 included patients, 5618 were diagnosed with a LR, RR or CBC. Five-year LR, RR and CBC rates decreased from 3.3 \%, 1.9 \% and 2.2 \% in 2003 to 1.5 \%, 1.6 \% and 1.5 \% in 2016, respectively, with fluctuations over the years. Slight increases were observed in RR rates for stage II-III, HR-/HER2+ and HR-/HER2-.Conclusion: (s). The observed overall decline in LR, RR and CBC rates could reflect more effective and personalized breast cancer treatment. Our results provide realistic insights in LR, RR and CBC rates and might contribute to further optimization of treatment and surveillance strategies.",

keywords = "UT-Gold-D, Contralateral breast cancer, Local recurrence, Real world data, Regional recurrence, Breast cancer",

author = "J. Meijer and \{van den Bongard\}, H.J.G.D. and L.B. Koppert and \{Menke-van der Houven van Oordt\}, C.W. and \{de Munck\}, L. and \{van Nijnatten\}, T.J.A. and \{van der Sangen\}, M.J.C. and R.J. Schipper and M.K. Schmidt and M.L. Smidt and W. Vreuls and \{van Maaren\}, M.C. and S. Siesling",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors. Published by Elsevier Ltd.",

year = "2026",

month = feb,

doi = "10.1016/j.breast.2025.104673",

language = "English",

volume = "85",

journal = "Breast",

issn = "0960-9776",

publisher = "Churchill Livingstone",

}

Meijer, J, van den Bongard, HJGD, Koppert, LB, Menke-van der Houven van Oordt, CW, de Munck, L, van Nijnatten, TJA, van der Sangen, MJC, Schipper, RJ, Schmidt, MK, Smidt, ML, Vreuls, W, van Maaren, MC & Siesling, S 2026, 'Trends in local, regional and contralateral breast tumor recurrence within five years after diagnosis in the Netherlands: A population-based study including 121347 patients', Breast, vol. 85, 104673. https://doi.org/10.1016/j.breast.2025.104673

TY - JOUR

T1 - Trends in local, regional and contralateral breast tumor recurrence within five years after diagnosis in the Netherlands

T2 - A population-based study including 121347 patients

AU - Meijer, J.

AU - van den Bongard, H.J.G.D.

AU - Koppert, L.B.

AU - Menke-van der Houven van Oordt, C.W.

AU - de Munck, L.

AU - van Nijnatten, T.J.A.

AU - van der Sangen, M.J.C.

AU - Schipper, R.J.

AU - Schmidt, M.K.

AU - Smidt, M.L.

AU - Vreuls, W.

AU - van Maaren, M.C.

AU - Siesling, S.

PY - 2026/2

Y1 - 2026/2

N2 - Background: The objective was to provide an overview of trends in five-year local recurrence (LR), regional recurrence (RR) and contralateral breast cancer (CBC) rates in the Netherlands from 2003 to 2008 and 2012–2016.Methods: Women ≥18 years diagnosed with primary early breast cancer between 2003-2008 and 2012–2016 in the Netherlands were included. LR was defined as invasive tumor on the same side as the primary breast cancer. RR was defined as regional lymph node metastasis. CBC was defined as second primary invasive breast tumor in the contralateral breast. Five-year LR, RR and CBC rates were calculated and stratified for age, stage, subtype, and grade.Results: Of the 121347 included patients, 5618 were diagnosed with a LR, RR or CBC. Five-year LR, RR and CBC rates decreased from 3.3 %, 1.9 % and 2.2 % in 2003 to 1.5 %, 1.6 % and 1.5 % in 2016, respectively, with fluctuations over the years. Slight increases were observed in RR rates for stage II-III, HR-/HER2+ and HR-/HER2-.Conclusion: (s). The observed overall decline in LR, RR and CBC rates could reflect more effective and personalized breast cancer treatment. Our results provide realistic insights in LR, RR and CBC rates and might contribute to further optimization of treatment and surveillance strategies.

AB - Background: The objective was to provide an overview of trends in five-year local recurrence (LR), regional recurrence (RR) and contralateral breast cancer (CBC) rates in the Netherlands from 2003 to 2008 and 2012–2016.Methods: Women ≥18 years diagnosed with primary early breast cancer between 2003-2008 and 2012–2016 in the Netherlands were included. LR was defined as invasive tumor on the same side as the primary breast cancer. RR was defined as regional lymph node metastasis. CBC was defined as second primary invasive breast tumor in the contralateral breast. Five-year LR, RR and CBC rates were calculated and stratified for age, stage, subtype, and grade.Results: Of the 121347 included patients, 5618 were diagnosed with a LR, RR or CBC. Five-year LR, RR and CBC rates decreased from 3.3 %, 1.9 % and 2.2 % in 2003 to 1.5 %, 1.6 % and 1.5 % in 2016, respectively, with fluctuations over the years. Slight increases were observed in RR rates for stage II-III, HR-/HER2+ and HR-/HER2-.Conclusion: (s). The observed overall decline in LR, RR and CBC rates could reflect more effective and personalized breast cancer treatment. Our results provide realistic insights in LR, RR and CBC rates and might contribute to further optimization of treatment and surveillance strategies.

KW - UT-Gold-D

KW - Contralateral breast cancer

KW - Local recurrence

KW - Real world data

KW - Regional recurrence

KW - Breast cancer

UR - https://www.scopus.com/pages/publications/105024709750

U2 - 10.1016/j.breast.2025.104673

DO - 10.1016/j.breast.2025.104673

M3 - Article

AN - SCOPUS:105024709750

SN - 0960-9776

VL - 85

JO - Breast

JF - Breast

M1 - 104673

ER -

Trends in local, regional and contralateral breast tumor recurrence within five years after diagnosis in the Netherlands: A population-based study including 121347 patients

Abstract

UN SDGs

Keywords

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