Trimethylene carbonate-based polymers for controlled drug delivery applications

Zheng Zhang (Corresponding Author), Dirk W. Grijpma, Jan Feijen

Research output: Contribution to journalConference articleAcademicpeer-review

6 Citations (Scopus)

Abstract

Microparticles, nanospheres, and micellar-like nanoparticles based on PTMC and mPEG–PTMC amphiphilic copolymers were prepared by double emulsion, single emulsion and salting out methods, and by conditioning of mPEG–PTMC films in water of 37 °C. The microparticles could effectively be loaded with hydrophilic compounds like BSA, lysozyme, and Coomassie® Brilliant Blue; the nanoparticles were effectively loaded with the hydrophobic drug dexamethasone. The release of these compounds is sustained and complete in 14–60 days
Original languageEnglish
Pages (from-to)e28-e29
JournalJournal of controlled release
Volume116
Issue number2
DOIs
Publication statusPublished - 2006
Event9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands
Duration: 5 Apr 20067 Apr 2006
Conference number: 9

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