Trimethylene carbonate-based polymers for controlled drug delivery applications

Zheng Zhang; Dirk W. Grijpma; Jan Feijen

doi:10.1016/j.jconrel.2006.09.032

Trimethylene carbonate-based polymers for controlled drug delivery applications

Zheng Zhang (Corresponding Author), Dirk W. Grijpma, Jan Feijen

Research output: Contribution to journal › Conference article › Academic › peer-review

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Abstract

Microparticles, nanospheres, and micellar-like nanoparticles based on PTMC and mPEG–PTMC amphiphilic copolymers were prepared by double emulsion, single emulsion and salting out methods, and by conditioning of mPEG–PTMC films in water of 37 °C. The microparticles could effectively be loaded with hydrophilic compounds like BSA, lysozyme, and Coomassie® Brilliant Blue; the nanoparticles were effectively loaded with the hydrophobic drug dexamethasone. The release of these compounds is sustained and complete in 14–60 days

Original language	English
Pages (from-to)	e28-e29
Journal	Journal of controlled release
Volume	116
Issue number	2
DOIs	https://doi.org/10.1016/j.jconrel.2006.09.032
Publication status	Published - 2006
Event	9th European Symposium on Controlled Drug Delivery, ESCDD 2006 - Noordwijk aan Zee, Netherlands Duration: 5 Apr 2006 → 7 Apr 2006 Conference number: 9

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10.1016/j.jconrel.2006.09.032

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title = "Trimethylene carbonate-based polymers for controlled drug delivery applications",

abstract = "Microparticles, nanospheres, and micellar-like nanoparticles based on PTMC and mPEG–PTMC amphiphilic copolymers were prepared by double emulsion, single emulsion and salting out methods, and by conditioning of mPEG–PTMC films in water of 37 °C. The microparticles could effectively be loaded with hydrophilic compounds like BSA, lysozyme, and Coomassie{\textregistered} Brilliant Blue; the nanoparticles were effectively loaded with the hydrophobic drug dexamethasone. The release of these compounds is sustained and complete in 14–60 days",

author = "Zheng Zhang and Grijpma, {Dirk W.} and Jan Feijen",

year = "2006",

doi = "10.1016/j.jconrel.2006.09.032",

language = "English",

volume = "116",

pages = "e28--e29",

journal = "Journal of controlled release",

issn = "0168-3659",

publisher = "Elsevier",

number = "2",

note = "9th European Symposium on Controlled Drug Delivery, ESCDD 2006, ESCDD ; Conference date: 05-04-2006 Through 07-04-2006",

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TY - JOUR

T1 - Trimethylene carbonate-based polymers for controlled drug delivery applications

AU - Zhang, Zheng

AU - Grijpma, Dirk W.

AU - Feijen, Jan

N1 - Conference code: 9

PY - 2006

Y1 - 2006

N2 - Microparticles, nanospheres, and micellar-like nanoparticles based on PTMC and mPEG–PTMC amphiphilic copolymers were prepared by double emulsion, single emulsion and salting out methods, and by conditioning of mPEG–PTMC films in water of 37 °C. The microparticles could effectively be loaded with hydrophilic compounds like BSA, lysozyme, and Coomassie® Brilliant Blue; the nanoparticles were effectively loaded with the hydrophobic drug dexamethasone. The release of these compounds is sustained and complete in 14–60 days

AB - Microparticles, nanospheres, and micellar-like nanoparticles based on PTMC and mPEG–PTMC amphiphilic copolymers were prepared by double emulsion, single emulsion and salting out methods, and by conditioning of mPEG–PTMC films in water of 37 °C. The microparticles could effectively be loaded with hydrophilic compounds like BSA, lysozyme, and Coomassie® Brilliant Blue; the nanoparticles were effectively loaded with the hydrophobic drug dexamethasone. The release of these compounds is sustained and complete in 14–60 days

U2 - 10.1016/j.jconrel.2006.09.032

DO - 10.1016/j.jconrel.2006.09.032

M3 - Conference article

SN - 0168-3659

VL - 116

SP - e28-e29

JO - Journal of controlled release

JF - Journal of controlled release

IS - 2

T2 - 9th European Symposium on Controlled Drug Delivery, ESCDD 2006

Y2 - 5 April 2006 through 7 April 2006

ER -

Trimethylene carbonate-based polymers for controlled drug delivery applications

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