Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration

Research output: Contribution to journalReview articleAcademicpeer-review

45 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) are considered to hold great therapeutic value for cell-based therapy and for tissue regeneration in particular. Recent evidence indicates that the main underlying mechanism for MSCs' beneficial effects in tissue regeneration is based on their capability to produce a large variety of bioactive trophic factors that stimulate neighboring parenchymal cells to start repairing damaged tissues. These new findings could potentially replace the classical paradigm of MSC differentiation and cell replacement. These bioactive factors have diverse actions like modulating the local immune system, enhancing angiogenesis, preventing cell apoptosis, and stimulating survival, proliferation, and differentiation of resident tissue specific cells. Therefore, MSCs are referred to as conductors of tissue repair and regeneration by secreting trophic mediators. In this review article, we have summarized the studies that focused on the trophic effects of MSC within the context of tissue regeneration. We will also highlight the various underlying mechanisms used by MSCs to act as trophic mediators. Besides the secretion of growth factors, we discuss two additional mechanisms that are likely to mediate MSC's beneficial effects in tissue regeneration, namely the production of extracellular vesicles and the formation of membrane nanotubes, which can both connect different cells and transfer a variety of trophic factors varying from proteins to mRNAs and miRNAs. Furthermore, we postulate that apoptosis of the MSCs is an integral part of the trophic effect during tissue repair.

Original languageEnglish
Pages (from-to)515-528
Number of pages14
JournalTissue engineering. Part B: Reviews
Volume23
Issue number6
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Tissue regeneration
Stem cells
Mesenchymal Stromal Cells
Regeneration
Tissue
Cell death
Repair
Apoptosis
Nanotubes
Immune system
Cell- and Tissue-Based Therapy
MicroRNAs
Cell Differentiation
Immune System
Intercellular Signaling Peptides and Proteins
Proteins
Membranes
Messenger RNA

Keywords

  • apoptosis
  • extracellular vesicles
  • growth factors
  • membrane nanotubes
  • mesenchymal stem cells
  • trophic effects

Cite this

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title = "Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration",
abstract = "Mesenchymal stem cells (MSCs) are considered to hold great therapeutic value for cell-based therapy and for tissue regeneration in particular. Recent evidence indicates that the main underlying mechanism for MSCs' beneficial effects in tissue regeneration is based on their capability to produce a large variety of bioactive trophic factors that stimulate neighboring parenchymal cells to start repairing damaged tissues. These new findings could potentially replace the classical paradigm of MSC differentiation and cell replacement. These bioactive factors have diverse actions like modulating the local immune system, enhancing angiogenesis, preventing cell apoptosis, and stimulating survival, proliferation, and differentiation of resident tissue specific cells. Therefore, MSCs are referred to as conductors of tissue repair and regeneration by secreting trophic mediators. In this review article, we have summarized the studies that focused on the trophic effects of MSC within the context of tissue regeneration. We will also highlight the various underlying mechanisms used by MSCs to act as trophic mediators. Besides the secretion of growth factors, we discuss two additional mechanisms that are likely to mediate MSC's beneficial effects in tissue regeneration, namely the production of extracellular vesicles and the formation of membrane nanotubes, which can both connect different cells and transfer a variety of trophic factors varying from proteins to mRNAs and miRNAs. Furthermore, we postulate that apoptosis of the MSCs is an integral part of the trophic effect during tissue repair.",
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Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration. / Fu, Yao; Karbaat, Lisanne; Wu, Ling; Leijten, Jeroen; Both, Sanne K.; Karperien, Marcel.

In: Tissue engineering. Part B: Reviews, Vol. 23, No. 6, 01.12.2017, p. 515-528.

Research output: Contribution to journalReview articleAcademicpeer-review

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