T2-weighted 3D fMRI using S2-SSFP at 7 tesla

Markus Barth; Heiko Meyer; Stephan A.R. Kannengiesser; Jonathan R. Polimeni; Lawrence L. Wald; David G. Norris

doi:10.1002/mrm.22283

T₂-weighted 3D fMRI using S₂-SSFP at 7 tesla

Markus Barth^*, Heiko Meyer, Stephan A.R. Kannengiesser, Jonathan R. Polimeni, Lawrence L. Wald, David G. Norris

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

In this study, the sensitivity of the S₂-steady-state free precession (SSFP) signal for functional MRI at 7 T was investigated. In order to achieve the necessary temporal resolution, a three-dimensional acquisition scheme with acceleration along two spatial axes was employed. Activation maps based on S₂-steady-state free precession data showed similar spatial localization of activation and sensitivity as spin-echo echo-planar imaging (SE-EPI), but data can be acquired with substantially lower power deposition. The functional sensitivity estimated by the average z-values was not significantly different for SE-EPI compared to the S₂-signal but was slightly lower for the S₂-signal (6.74 ± 0.32 for the TR = 15 ms protocol and 7.51 ± 0.78 for the TR = 27 ms protocol) compared to SE-EPI (7.49 ± 1.44 and 8.05 ± 1.67) using the same activated voxels, respectively. The relative signal changes in these voxels upon activation were slightly lower for SE-EPI (2.37% ± 0.18%) compared to the TR 5 15 ms S₂-SSFP protocol (2.75% ± 0.53%) and significantly lower than the TR = 27 ms protocol (5.38% ± 1.28%), in line with simulations results. The large relative signal change for the long TR SSFP protocol can be explained by contributions from multiple coherence pathways and the low intrinsic intensity of the S₂ signal. In conclusion, whole-brain T₂-weighted functional MRI with negligible image distortion at 7 T is feasible using the S₂-SSFP sequence and partially parallel imaging.

Original language	English
Pages (from-to)	1015-1020
Number of pages	6
Journal	Magnetic resonance in medicine
Volume	63
Issue number	4
DOIs	https://doi.org/10.1002/mrm.22283
Publication status	Published - May 2010
Externally published	Yes

Keywords

7 tesla
BOLD
Brain
Neuroimaging
Steady-state free procession
n/a OA procedure

Access to Document

10.1002/mrm.22283

Cite this

@article{c3c98ca75a3d4653ae9d2360eb7f1ef0,

title = "T2-weighted 3D fMRI using S2-SSFP at 7 tesla",

abstract = "In this study, the sensitivity of the S2-steady-state free precession (SSFP) signal for functional MRI at 7 T was investigated. In order to achieve the necessary temporal resolution, a three-dimensional acquisition scheme with acceleration along two spatial axes was employed. Activation maps based on S2-steady-state free precession data showed similar spatial localization of activation and sensitivity as spin-echo echo-planar imaging (SE-EPI), but data can be acquired with substantially lower power deposition. The functional sensitivity estimated by the average z-values was not significantly different for SE-EPI compared to the S2-signal but was slightly lower for the S2-signal (6.74 ± 0.32 for the TR = 15 ms protocol and 7.51 ± 0.78 for the TR = 27 ms protocol) compared to SE-EPI (7.49 ± 1.44 and 8.05 ± 1.67) using the same activated voxels, respectively. The relative signal changes in these voxels upon activation were slightly lower for SE-EPI (2.37% ± 0.18%) compared to the TR 5 15 ms S2-SSFP protocol (2.75% ± 0.53%) and significantly lower than the TR = 27 ms protocol (5.38% ± 1.28%), in line with simulations results. The large relative signal change for the long TR SSFP protocol can be explained by contributions from multiple coherence pathways and the low intrinsic intensity of the S2 signal. In conclusion, whole-brain T2-weighted functional MRI with negligible image distortion at 7 T is feasible using the S2-SSFP sequence and partially parallel imaging.",

keywords = "7 tesla, BOLD, Brain, Neuroimaging, Steady-state free procession, n/a OA procedure",

author = "Markus Barth and Heiko Meyer and Kannengiesser, {Stephan A.R.} and Polimeni, {Jonathan R.} and Wald, {Lawrence L.} and Norris, {David G.}",

year = "2010",

month = may,

doi = "10.1002/mrm.22283",

language = "English",

volume = "63",

pages = "1015--1020",

journal = "Magnetic resonance in medicine",

issn = "0740-3194",

publisher = "Wiley",

number = "4",

}

TY - JOUR

T1 - T2-weighted 3D fMRI using S2-SSFP at 7 tesla

AU - Barth, Markus

AU - Meyer, Heiko

AU - Kannengiesser, Stephan A.R.

AU - Polimeni, Jonathan R.

AU - Wald, Lawrence L.

AU - Norris, David G.

PY - 2010/5

Y1 - 2010/5

N2 - In this study, the sensitivity of the S2-steady-state free precession (SSFP) signal for functional MRI at 7 T was investigated. In order to achieve the necessary temporal resolution, a three-dimensional acquisition scheme with acceleration along two spatial axes was employed. Activation maps based on S2-steady-state free precession data showed similar spatial localization of activation and sensitivity as spin-echo echo-planar imaging (SE-EPI), but data can be acquired with substantially lower power deposition. The functional sensitivity estimated by the average z-values was not significantly different for SE-EPI compared to the S2-signal but was slightly lower for the S2-signal (6.74 ± 0.32 for the TR = 15 ms protocol and 7.51 ± 0.78 for the TR = 27 ms protocol) compared to SE-EPI (7.49 ± 1.44 and 8.05 ± 1.67) using the same activated voxels, respectively. The relative signal changes in these voxels upon activation were slightly lower for SE-EPI (2.37% ± 0.18%) compared to the TR 5 15 ms S2-SSFP protocol (2.75% ± 0.53%) and significantly lower than the TR = 27 ms protocol (5.38% ± 1.28%), in line with simulations results. The large relative signal change for the long TR SSFP protocol can be explained by contributions from multiple coherence pathways and the low intrinsic intensity of the S2 signal. In conclusion, whole-brain T2-weighted functional MRI with negligible image distortion at 7 T is feasible using the S2-SSFP sequence and partially parallel imaging.

AB - In this study, the sensitivity of the S2-steady-state free precession (SSFP) signal for functional MRI at 7 T was investigated. In order to achieve the necessary temporal resolution, a three-dimensional acquisition scheme with acceleration along two spatial axes was employed. Activation maps based on S2-steady-state free precession data showed similar spatial localization of activation and sensitivity as spin-echo echo-planar imaging (SE-EPI), but data can be acquired with substantially lower power deposition. The functional sensitivity estimated by the average z-values was not significantly different for SE-EPI compared to the S2-signal but was slightly lower for the S2-signal (6.74 ± 0.32 for the TR = 15 ms protocol and 7.51 ± 0.78 for the TR = 27 ms protocol) compared to SE-EPI (7.49 ± 1.44 and 8.05 ± 1.67) using the same activated voxels, respectively. The relative signal changes in these voxels upon activation were slightly lower for SE-EPI (2.37% ± 0.18%) compared to the TR 5 15 ms S2-SSFP protocol (2.75% ± 0.53%) and significantly lower than the TR = 27 ms protocol (5.38% ± 1.28%), in line with simulations results. The large relative signal change for the long TR SSFP protocol can be explained by contributions from multiple coherence pathways and the low intrinsic intensity of the S2 signal. In conclusion, whole-brain T2-weighted functional MRI with negligible image distortion at 7 T is feasible using the S2-SSFP sequence and partially parallel imaging.

KW - 7 tesla

KW - BOLD

KW - Brain

KW - Neuroimaging

KW - Steady-state free procession

KW - n/a OA procedure

UR - http://www.scopus.com/inward/record.url?scp=77950613394&partnerID=8YFLogxK

U2 - 10.1002/mrm.22283

DO - 10.1002/mrm.22283

M3 - Article

C2 - 20373402

AN - SCOPUS:77950613394

SN - 0740-3194

VL - 63

SP - 1015

EP - 1020

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

IS - 4

ER -

T₂-weighted 3D fMRI using S₂-SSFP at 7 tesla

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this