Here, we report a breast tumour-on-a-chip platform to evaluate the penetration of nanomedicines in 3D tumour spheroids, as a function of the tumour spheroid cellular composition. Mouse multicellular tumour mono-culture spheroids and cancer cell-fibroblast co-culture spheroids were exposed to silica nanoparticles (NPs) (30 or 100nm) or liposomes (100nm) at various flowrates, mimicking the shear stress levels found in vivo. Results revealed that the NP penetration was influenced by the shear stress, and that the presence of fibroblasts in the tumour spheroids greatly reduced the penetration depth of the nanoparticles.
|Title of host publication||MicroTAS 2018|
|Subtitle of host publication||22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Editors||Fan-Gang Tseng, Gwo-Bin Lee|
|Publisher||The Chemical and Biological Microsystems Society|
|Number of pages||2|
|Publication status||Published - 13 Nov 2018|
|Event||22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Province of China|
Duration: 10 Nov 2018 → 15 Nov 2018
Conference number: 22
|Conference||22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018|
|Abbreviated title||MicroTAS 2018|
|Country||Taiwan, Province of China|
|Period||10/11/18 → 15/11/18|
- Tumour Spheroid
Blondé, J-B., Priwitaningrum, D., Prakash, J., & le Gac, S. (2018). Tumour-on-a-chip platform to evaluate nanoparticles penetration in 3D co-culture tumour spheroids. In F-G. Tseng, & G-B. Lee (Eds.), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1959-1960). The Chemical and Biological Microsystems Society.