Tumour tissue: Who is in control?

Martine Corrette Ploem; Valesca P. Retèl; Sabine C. Linn; Hester H. van Boven; Marjanka K. Schmidt; Jean Philippe de Jong; Joseph K.M. Gevers; Wim H. van Harten

doi:10.1016/S1470-2045(09)70318-3

Tumour tissue: Who is in control?

Martine Corrette Ploem, Valesca P. Retèl, Sabine C. Linn, Hester H. van Boven, Marjanka K. Schmidt, Jean Philippe de Jong, Joseph K.M. Gevers, Wim H. van Harten (Corresponding Author)

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Abstract

Recent developments in genomics have resulted in the increased availability of gene profiles for early diagnosis and prognosis in breast cancer. A request from a Dutch woman to have her tumour tissue tested years after treatment confronted the Netherlands Cancer Institute (NKI) and its staff with legal, ethical, and practical questions regarding patients' rights in relation to residual tissue storage and its use for clinical purposes. Was her tissue still available? If so, could she demand that the test be carried out or her tissue be transferred to another hospital? As it became apparent that appropriate guidance was lacking in this area, we developed guidelines on the issue, with the involvement of relevant professionals and patient representatives within the framework of a Technology Assessment project.1

Gene-expression profiling is an important development that is likely to predict the diagnosis and prognosis of malignant disease more accurately than existing clinicopathological parameters.2 Although gene-expression profiling is not yet routine, several tests are already applied in clinical practice. Additionally, the 70-gene signature (MammaPrint), which uses microarrays on fresh frozen tumour tissue, is being tested in a multicentre randomised trial (MINDACT).3 However, for such tests to be successful it is essential that sufficient tumour tissue is available.

Original language	English
Pages (from-to)	9-11
Journal	Lancet oncology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/S1470-2045(09)70318-3
Publication status	Published - 2010

Keywords

IR-71403
METIS-261084

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10.1016/S1470-2045(09)70318-3

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title = "Tumour tissue: Who is in control?",

abstract = "Recent developments in genomics have resulted in the increased availability of gene profiles for early diagnosis and prognosis in breast cancer. A request from a Dutch woman to have her tumour tissue tested years after treatment confronted the Netherlands Cancer Institute (NKI) and its staff with legal, ethical, and practical questions regarding patients' rights in relation to residual tissue storage and its use for clinical purposes. Was her tissue still available? If so, could she demand that the test be carried out or her tissue be transferred to another hospital? As it became apparent that appropriate guidance was lacking in this area, we developed guidelines on the issue, with the involvement of relevant professionals and patient representatives within the framework of a Technology Assessment project.1Gene-expression profiling is an important development that is likely to predict the diagnosis and prognosis of malignant disease more accurately than existing clinicopathological parameters.2 Although gene-expression profiling is not yet routine, several tests are already applied in clinical practice. Additionally, the 70-gene signature (MammaPrint), which uses microarrays on fresh frozen tumour tissue, is being tested in a multicentre randomised trial (MINDACT).3 However, for such tests to be successful it is essential that sufficient tumour tissue is available.",

keywords = "IR-71403, METIS-261084",

author = "Ploem, {Martine Corrette} and Ret{\`e}l, {Valesca P.} and Linn, {Sabine C.} and {van Boven}, {Hester H.} and Schmidt, {Marjanka K.} and {de Jong}, {Jean Philippe} and Gevers, {Joseph K.M.} and {van Harten}, {Wim H.}",

year = "2010",

doi = "10.1016/S1470-2045(09)70318-3",

language = "English",

volume = "11",

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T2 - Who is in control?

AU - Ploem, Martine Corrette

AU - Retèl, Valesca P.

AU - Linn, Sabine C.

AU - van Boven, Hester H.

AU - Schmidt, Marjanka K.

AU - de Jong, Jean Philippe

AU - Gevers, Joseph K.M.

AU - van Harten, Wim H.

PY - 2010

Y1 - 2010

N2 - Recent developments in genomics have resulted in the increased availability of gene profiles for early diagnosis and prognosis in breast cancer. A request from a Dutch woman to have her tumour tissue tested years after treatment confronted the Netherlands Cancer Institute (NKI) and its staff with legal, ethical, and practical questions regarding patients' rights in relation to residual tissue storage and its use for clinical purposes. Was her tissue still available? If so, could she demand that the test be carried out or her tissue be transferred to another hospital? As it became apparent that appropriate guidance was lacking in this area, we developed guidelines on the issue, with the involvement of relevant professionals and patient representatives within the framework of a Technology Assessment project.1Gene-expression profiling is an important development that is likely to predict the diagnosis and prognosis of malignant disease more accurately than existing clinicopathological parameters.2 Although gene-expression profiling is not yet routine, several tests are already applied in clinical practice. Additionally, the 70-gene signature (MammaPrint), which uses microarrays on fresh frozen tumour tissue, is being tested in a multicentre randomised trial (MINDACT).3 However, for such tests to be successful it is essential that sufficient tumour tissue is available.

AB - Recent developments in genomics have resulted in the increased availability of gene profiles for early diagnosis and prognosis in breast cancer. A request from a Dutch woman to have her tumour tissue tested years after treatment confronted the Netherlands Cancer Institute (NKI) and its staff with legal, ethical, and practical questions regarding patients' rights in relation to residual tissue storage and its use for clinical purposes. Was her tissue still available? If so, could she demand that the test be carried out or her tissue be transferred to another hospital? As it became apparent that appropriate guidance was lacking in this area, we developed guidelines on the issue, with the involvement of relevant professionals and patient representatives within the framework of a Technology Assessment project.1Gene-expression profiling is an important development that is likely to predict the diagnosis and prognosis of malignant disease more accurately than existing clinicopathological parameters.2 Although gene-expression profiling is not yet routine, several tests are already applied in clinical practice. Additionally, the 70-gene signature (MammaPrint), which uses microarrays on fresh frozen tumour tissue, is being tested in a multicentre randomised trial (MINDACT).3 However, for such tests to be successful it is essential that sufficient tumour tissue is available.

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KW - METIS-261084

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DO - 10.1016/S1470-2045(09)70318-3

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EP - 11

JO - Lancet oncology

JF - Lancet oncology

SN - 1470-2045

IS - 1

ER -

Tumour tissue: Who is in control?

Abstract

Keywords

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