Tuning the properties of PS–PIAT block copolymers and their assembly into polymersomes

H.P.M. de Hoog, D.M. Vriezema, Madhavan Nallani, S. Kuiper, Jeroen Johannes Lambertus Maria Cornelissen, A.E. Rowan, Roeland Nolte

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The diblock copolymer polystyrene-b-polyisocyanoalanine(2-thiophene-3-yl-ethyl)amide (PS–PIAT) was prepared by reacting the isocyanide monomer (1) with a Ni(II) initiator complex prepared from polystyrene amine (PS40NH2), either obtained by atom transfer radical polymerization (ATRP) or anionic polymerization (AP). It was found that polymerization of optically pure 1 followed first-order kinetics in monomer concentration and resulted in the formation of insoluble block copolymers, whereas the rate of polymerization of optical mixtures of 1 was retarded and yielded block copolymers that were better soluble. Furthermore, PS–PIAT polymersomes of which the PS-block was prepared by AP were more stable than polymersomes of which the PS-block was prepared by ATRP, as was indicated by combined turbidity and dynamic light scattering (DLS) measurements on the aggregate solutions.
Original languageUndefined
Pages (from-to)1003-1010
JournalSoft matter
Publication statusPublished - 2008


  • METIS-306494

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