Tuning the properties of PS–PIAT block copolymers and their assembly into polymersomes

Hans-Peter M. de Hoog; Dennis M. Vriezema; Madhavan Nallani; Suzanne Kuiper; Jeroen J.L.M. Cornelissen; A.E. Rowan; Roeland J.M. Nolte

doi:10.1039/B716044E

Tuning the properties of PS–PIAT block copolymers and their assembly into polymersomes

Hans-Peter M. de Hoog, Dennis M. Vriezema, Madhavan Nallani, Suzanne Kuiper, Jeroen J.L.M. Cornelissen^*, A.E. Rowan, Roeland J.M. Nolte

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

The diblock copolymer polystyrene-b-polyisocyanoalanine(2-thiophene-3-yl-ethyl)amide (PS–PIAT) was prepared by reacting the isocyanide monomer (1) with a Ni(II) initiator complex prepared from polystyrene amine (PS40NH2), either obtained by atom transfer radical polymerization (ATRP) or anionic polymerization (AP). It was found that polymerization of optically pure 1 followed first-order kinetics in monomer concentration and resulted in the formation of insoluble block copolymers, whereas the rate of polymerization of optical mixtures of 1 was retarded and yielded block copolymers that were better soluble. Furthermore, PS–PIAT polymersomes of which the PS-block was prepared by AP were more stable than polymersomes of which the PS-block was prepared by ATRP, as was indicated by combined turbidity and dynamic light scattering (DLS) measurements on the aggregate solutions.

Original language	English
Pages (from-to)	1003-1010
Journal	Soft matter
Volume	4
DOIs	https://doi.org/10.1039/B716044E
Publication status	Published - 2008
Externally published	Yes

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10.1039/B716044E

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@article{8db711c8d68944b2b8f50814c15aa15e,

title = "Tuning the properties of PS–PIAT block copolymers and their assembly into polymersomes",

abstract = "The diblock copolymer polystyrene-b-polyisocyanoalanine(2-thiophene-3-yl-ethyl)amide (PS–PIAT) was prepared by reacting the isocyanide monomer (1) with a Ni(II) initiator complex prepared from polystyrene amine (PS40NH2), either obtained by atom transfer radical polymerization (ATRP) or anionic polymerization (AP). It was found that polymerization of optically pure 1 followed first-order kinetics in monomer concentration and resulted in the formation of insoluble block copolymers, whereas the rate of polymerization of optical mixtures of 1 was retarded and yielded block copolymers that were better soluble. Furthermore, PS–PIAT polymersomes of which the PS-block was prepared by AP were more stable than polymersomes of which the PS-block was prepared by ATRP, as was indicated by combined turbidity and dynamic light scattering (DLS) measurements on the aggregate solutions.",

keywords = "n/a OA procedure",

author = "{de Hoog}, {Hans-Peter M.} and Vriezema, {Dennis M.} and Madhavan Nallani and Suzanne Kuiper and Cornelissen, {Jeroen J.L.M.} and A.E. Rowan and Nolte, {Roeland J.M.}",

year = "2008",

doi = "10.1039/B716044E",

language = "English",

volume = "4",

pages = "1003--1010",

journal = "Soft matter",

issn = "1744-683X",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Tuning the properties of PS–PIAT block copolymers and their assembly into polymersomes

AU - de Hoog, Hans-Peter M.

AU - Vriezema, Dennis M.

AU - Nallani, Madhavan

AU - Kuiper, Suzanne

AU - Cornelissen, Jeroen J.L.M.

AU - Rowan, A.E.

AU - Nolte, Roeland J.M.

PY - 2008

Y1 - 2008

N2 - The diblock copolymer polystyrene-b-polyisocyanoalanine(2-thiophene-3-yl-ethyl)amide (PS–PIAT) was prepared by reacting the isocyanide monomer (1) with a Ni(II) initiator complex prepared from polystyrene amine (PS40NH2), either obtained by atom transfer radical polymerization (ATRP) or anionic polymerization (AP). It was found that polymerization of optically pure 1 followed first-order kinetics in monomer concentration and resulted in the formation of insoluble block copolymers, whereas the rate of polymerization of optical mixtures of 1 was retarded and yielded block copolymers that were better soluble. Furthermore, PS–PIAT polymersomes of which the PS-block was prepared by AP were more stable than polymersomes of which the PS-block was prepared by ATRP, as was indicated by combined turbidity and dynamic light scattering (DLS) measurements on the aggregate solutions.

AB - The diblock copolymer polystyrene-b-polyisocyanoalanine(2-thiophene-3-yl-ethyl)amide (PS–PIAT) was prepared by reacting the isocyanide monomer (1) with a Ni(II) initiator complex prepared from polystyrene amine (PS40NH2), either obtained by atom transfer radical polymerization (ATRP) or anionic polymerization (AP). It was found that polymerization of optically pure 1 followed first-order kinetics in monomer concentration and resulted in the formation of insoluble block copolymers, whereas the rate of polymerization of optical mixtures of 1 was retarded and yielded block copolymers that were better soluble. Furthermore, PS–PIAT polymersomes of which the PS-block was prepared by AP were more stable than polymersomes of which the PS-block was prepared by ATRP, as was indicated by combined turbidity and dynamic light scattering (DLS) measurements on the aggregate solutions.

KW - n/a OA procedure

U2 - 10.1039/B716044E

DO - 10.1039/B716044E

M3 - Article

SN - 1744-683X

VL - 4

SP - 1003

EP - 1010

JO - Soft matter

JF - Soft matter

ER -

Tuning the properties of PS–PIAT block copolymers and their assembly into polymersomes

Abstract

Keywords

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