Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts

Sjoukje M. Schoustra, Daniele Piras, Roeland Huijink, Tim J.P.M. op 't Root, Laurens Alink, Wouter Muller Kobold, Wiendelt Steenbergen, Srirang Manohar*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)
113 Downloads (Pure)


We present the Twente Photoacoustic Mammoscope 2, a photoacoustic breast imaging system employing a tomographic configuration. It images one breast pendant inside an imaging tank filled with water while a woman lies prone on a bed. A dual-head laser (755 and 1064 nm) illuminates the breast with one beam directed at the nipple and nine beams directed at the sides. Ultrasound signals are detected using 12 arc-shaped arrays, each curving along the pendant breast. Each array comprises 32 piezocomposite elements each with a center frequency of 1 MHz. The imaging tank and the ultrasound arrays rotate around the breast in steps to obtain additional multiple projections. Three-dimensional images are reconstructed using a filtered backprojection algorithm. The system is described in detail, and measurements on a test object are presented. As part of a preliminary study to assess the system's in vivo performance, the breasts of two healthy volunteers were imaged. These images show the breast contour, the nipple, and the vascular anatomy within the breast. In the nipple of one case, multiple high-intensity "hot spots" are observed, which we suspect are associated with the lactiferous ducts terminating in the nipple.

Original languageEnglish
Article number121909
Number of pages12
JournalJournal of biomedical optics
Issue number12
Publication statusPublished - 1 Dec 2019


  • Breast cancer
  • Breast imaging
  • Photoacoustics
  • Tomography

Cite this