Two-phase (bio)catalytic reactions in a table-top centrifugal contact separator

Gerard N. Kraai, Floris Van Zwol, Boelo Schuur, Hero J. Heeres, Johannes G. De Vries (Corresponding Author)

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)


(Figure Presented) A new spin on catalysis: A table-top centrifugal contact separator allows for fast continuous two-phase reactions to be performed by intimately mixing two immiscible phases and then separating them. Such a device has been used to produce biodiesel from sunflower oil and MeOH/NaOMe. A lipase-catalyzed esterification of oleic acid with nBuOH (see picture) also proceeds with high conversion and can be run for up to 13 h.

Original languageEnglish
Pages (from-to)3905-3908
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number21
Publication statusPublished - 13 May 2008
Externally publishedYes


  • Biphasic catalysis
  • Enzyme catalysis
  • Esterification
  • Fatty acids
  • Sustainable chemistry


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