Two-year clinical outcome of all-comers treated with three highly dissimilar contemporary coronary drug-eluting stents in the randomised BIO-RESORT trial

Marlies M. Kok, Rosaly A. Buiten, Peter W. Danse, Carl E. Schotborgh, Martijn Scholte, Marc Hartmann, Martin G. Stoel, K.G. van Houwelingen, Gerard C.M. Linssen, Carine Doggen, Clemens von Birgelen (Corresponding Author), Paolo Zocca

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Abstract

Aims: The aim of the study was to evaluate the two-year clinical outcome of all-comer trial participants who were treated with two very different thin-strut biodegradable polymer versus thin-strut durable polymer drug-eluting stents (DES). Prolonged clinical outcome after discontinuation of dual antiplatelet therapy is of particular interest, given the highly dissimilar polymer types, amount, distribution, and degradation speed of both biodegradable polymer DES.

Methods and results: The BIO-RESORT trial (NCT01674803) randomly assigned 3,514 patients to treatment with biodegradable polymer SYNERGY everolimus-eluting stents (EES) or Orsiro sirolimus-eluting stents (SES), or durable polymer Resolute Integrity zotarolimus-eluting stents (ZES). At two-year follow-up (available in 98.8%), the rate of the primary composite endpoint target vessel failure (TVF) was 8.3% in ZES versus 6.8% in EES (p=0.19) and 6.6% in SES (p=0.12). Landmark analyses at one year revealed differences between SES and ZES in the rates of target lesion revascularisation and target lesion failure (0.6% vs. 1.5%, p=0.04, and 1.1% vs. 2.4%, p=0.02, respectively) as well as other composite secondary endpoints that reached statistical significance.

Conclusions: At two-year follow-up, there was no significant between-DES difference in the rates of the primary endpoint. Landmark analyses provided a signal that the use of SES versus ZES might reduce the risk of repeat revascularisation after one-year follow-up.
Original languageEnglish
Pages (from-to)915-923
Number of pages9
JournalEuroIntervention
Volume14
Issue number8
Early online date23 May 2018
DOIs
Publication statusPublished - 20 Oct 2018

Keywords

  • Clinical trials
  • Drug-eluting stent
  • NSTEMI
  • STEMI
  • Stable angina

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