Ultrahigh-Throughput Production of Monodisperse and Multifunctional Janus Microparticles Using in-Air Microfluidics

Tom Kamperman* (Corresponding Author), Vasileios D. Trikalitis, Marcel Karperien, Claas Willem Visser, Jeroen Leijten (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)
217 Downloads (Pure)


Compartmentalized Janus microparticles advance many applications ranging from chemical synthesis to consumer electronics. Although these particles can be accurately manufactured using microfluidic droplet generators, the per-nozzle throughputs are relatively low (∼μL/min). Here, we use "in-air microfluidics" to combine liquid microjets in midair, thereby enabling orders of magnitude faster production of Janus microparticles (∼mL/min) as compared to chip-based microfluidics. Monodisperse Janus microparticles with diameters between 50 and 500 μm, tunable compartment sizes, and functional cargo are controllably produced. Furthermore, these microparticles are designed as magnetically steerable microreactors, which represents a novel tool to perform enzymatic cascade reactions within continuous fluid flows.

Original languageEnglish
Pages (from-to)23433-23438
Number of pages6
JournalACS Applied Materials and Interfaces
Issue number28
Publication statusPublished - 18 Jul 2018


  • UT-Hybrid-D
  • Hydrogels
  • Liquid jets
  • Magnetic steering
  • Microreactors
  • Compartmentalization


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