Ultrasensitive Detection and in Situ Imaging of Analytes on Graphene Oxide Analogues Using Enhanced Raman Spectroscopy

Sachin Nair*, Jun Gao, Cees Otto, Michael H.G. Duits, Frieder Mugele*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

We demonstrate how algorithm-improved confocal Raman microscopy (ai-CRM), in combination with chemical enhancement by two-dimensional substrates, can be used as an ultrasensitive detection method for rhodamine (R6G) molecules adsorbed from aqueous solutions. After developing a protocol for laser-induced reduction of graphene oxide, followed by noninvasive Raman imaging, a limit of detection (LOD) of 5 × 10-10M R6G was achieved using ai-CRM. An equivalent subnanomolar LOD was also achieved on another graphene oxide analogue −UV/ozone-oxidized graphene. These record-breaking detection capabilities also enabled us to study the adsorption kinetics and image the spatial distribution of the adsorbed R6G. These findings indicate a strong potential for algorithm-improved graphene-enhanced Raman spectroscopy as a facile method for detecting, imaging, and quantifying trace amounts of adsorbing molecules on a variety of 2D substrates.

Original languageEnglish
Pages (from-to)12966-12972
Number of pages7
JournalAnalytical chemistry
Volume93
Issue number38
DOIs
Publication statusPublished - 28 Sep 2021

Keywords

  • UT-Hybrid-D

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