Ultrasound Contrast Agent Microbubble Dynamics

M.L.J. Overvelde, Henk Vos, N. de Jong, Michel Versluis

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Abstract

Ultrasound contrast agents are traditionally used in ultrasound-assisted organ perfusion imaging. Recently the use of coated microbubbles has been proposed for molecular imaging applications where the bubbles are covered with a layer of targeting ligands to bind specifically to their target cells. In this chapter we describe contrast agent microbubble behavior starting from the details of free bubble dynamics leading to a set of equations describing the dynamics of coated microbubbles. Experimentally, the dynamics of ultrasound contrast agent microbubbles is temporally resolved using the ultra-high speed camera Brandaris 128. The influence of a neighboring wall is investigated by combining the Brandaris camera with optical tweezers. It was observed that the presence of the wall can alter the bubble response. A detailed description of the bubble-wall interaction may therefore lead to improved molecular imaging strategies
Original languageUndefined
Title of host publicationUltrasound Contrast Agents: Targeting and Processing Methods for Theranostics
EditorsGaio Paradossi, Paolo Pellegretti, Andrea Trucco
Place of PublicationMilaan
PublisherSpringer
Pages79-97
Number of pages20
ISBN (Print)9788847014930
DOIs
Publication statusPublished - 2010

Publication series

NameSpringer Books in Biomedical Engineering
PublisherSpringer

Keywords

  • METIS-263444
  • IR-79279

Cite this

Overvelde, M. L. J., Vos, H., de Jong, N., & Versluis, M. (2010). Ultrasound Contrast Agent Microbubble Dynamics. In G. Paradossi, P. Pellegretti, & A. Trucco (Eds.), Ultrasound Contrast Agents: Targeting and Processing Methods for Theranostics (pp. 79-97). (Springer Books in Biomedical Engineering). Milaan: Springer. https://doi.org/10.1007/978-88-470-1494-7_7