Ultrasound Contrast Agent Microbubble Dynamics

M.L.J. Overvelde, Henk Vos, N. de Jong, Michel Versluis

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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Abstract

Ultrasound contrast agents are traditionally used in ultrasound-assisted organ perfusion imaging. Recently the use of coated microbubbles has been proposed for molecular imaging applications where the bubbles are covered with a layer of targeting ligands to bind specifically to their target cells. In this chapter we describe contrast agent microbubble behavior starting from the details of free bubble dynamics leading to a set of equations describing the dynamics of coated microbubbles. Experimentally, the dynamics of ultrasound contrast agent microbubbles is temporally resolved using the ultra-high speed camera Brandaris 128. The influence of a neighboring wall is investigated by combining the Brandaris camera with optical tweezers. It was observed that the presence of the wall can alter the bubble response. A detailed description of the bubble-wall interaction may therefore lead to improved molecular imaging strategies
Original languageUndefined
Title of host publicationUltrasound Contrast Agents: Targeting and Processing Methods for Theranostics
EditorsGaio Paradossi, Paolo Pellegretti, Andrea Trucco
Place of PublicationMilaan
PublisherSpringer
Pages79-97
Number of pages20
ISBN (Print)9788847014930
DOIs
Publication statusPublished - 2010

Publication series

NameSpringer Books in Biomedical Engineering
PublisherSpringer

Keywords

  • METIS-263444
  • IR-79279

Cite this

Overvelde, M. L. J., Vos, H., de Jong, N., & Versluis, M. (2010). Ultrasound Contrast Agent Microbubble Dynamics. In G. Paradossi, P. Pellegretti, & A. Trucco (Eds.), Ultrasound Contrast Agents: Targeting and Processing Methods for Theranostics (pp. 79-97). (Springer Books in Biomedical Engineering). Milaan: Springer. https://doi.org/10.1007/978-88-470-1494-7_7
Overvelde, M.L.J. ; Vos, Henk ; de Jong, N. ; Versluis, Michel. / Ultrasound Contrast Agent Microbubble Dynamics. Ultrasound Contrast Agents: Targeting and Processing Methods for Theranostics. editor / Gaio Paradossi ; Paolo Pellegretti ; Andrea Trucco. Milaan : Springer, 2010. pp. 79-97 (Springer Books in Biomedical Engineering).
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Overvelde, MLJ, Vos, H, de Jong, N & Versluis, M 2010, Ultrasound Contrast Agent Microbubble Dynamics. in G Paradossi, P Pellegretti & A Trucco (eds), Ultrasound Contrast Agents: Targeting and Processing Methods for Theranostics. Springer Books in Biomedical Engineering, Springer, Milaan, pp. 79-97. https://doi.org/10.1007/978-88-470-1494-7_7

Ultrasound Contrast Agent Microbubble Dynamics. / Overvelde, M.L.J.; Vos, Henk; de Jong, N.; Versluis, Michel.

Ultrasound Contrast Agents: Targeting and Processing Methods for Theranostics. ed. / Gaio Paradossi; Paolo Pellegretti; Andrea Trucco. Milaan : Springer, 2010. p. 79-97 (Springer Books in Biomedical Engineering).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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T1 - Ultrasound Contrast Agent Microbubble Dynamics

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N2 - Ultrasound contrast agents are traditionally used in ultrasound-assisted organ perfusion imaging. Recently the use of coated microbubbles has been proposed for molecular imaging applications where the bubbles are covered with a layer of targeting ligands to bind specifically to their target cells. In this chapter we describe contrast agent microbubble behavior starting from the details of free bubble dynamics leading to a set of equations describing the dynamics of coated microbubbles. Experimentally, the dynamics of ultrasound contrast agent microbubbles is temporally resolved using the ultra-high speed camera Brandaris 128. The influence of a neighboring wall is investigated by combining the Brandaris camera with optical tweezers. It was observed that the presence of the wall can alter the bubble response. A detailed description of the bubble-wall interaction may therefore lead to improved molecular imaging strategies

AB - Ultrasound contrast agents are traditionally used in ultrasound-assisted organ perfusion imaging. Recently the use of coated microbubbles has been proposed for molecular imaging applications where the bubbles are covered with a layer of targeting ligands to bind specifically to their target cells. In this chapter we describe contrast agent microbubble behavior starting from the details of free bubble dynamics leading to a set of equations describing the dynamics of coated microbubbles. Experimentally, the dynamics of ultrasound contrast agent microbubbles is temporally resolved using the ultra-high speed camera Brandaris 128. The influence of a neighboring wall is investigated by combining the Brandaris camera with optical tweezers. It was observed that the presence of the wall can alter the bubble response. A detailed description of the bubble-wall interaction may therefore lead to improved molecular imaging strategies

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Overvelde MLJ, Vos H, de Jong N, Versluis M. Ultrasound Contrast Agent Microbubble Dynamics. In Paradossi G, Pellegretti P, Trucco A, editors, Ultrasound Contrast Agents: Targeting and Processing Methods for Theranostics. Milaan: Springer. 2010. p. 79-97. (Springer Books in Biomedical Engineering). https://doi.org/10.1007/978-88-470-1494-7_7