Ultrasound contrast agents: resonances of coated bubbles

Sander Martijn van der Meer

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

57 Downloads (Pure)

Abstract

The Brandaris 128 high speed camera was designed and built in order to analyze the dynamics of single oscillating contrast agent microbubbles under influence of ultrasound. In this thesis we report on our findings. First, in Ch. 2, a new model was introduced which takes into account the physical properties of a lipidmonolayer coating on a gasmicrobubble. Three parameters describe the properties of the shell: a buckling radius, the compressibility of the shell, and a break-up shell tension. The model presents an original non-linear behavior at large amplitude oscillations, termed compression–only, induced by the buckling of the lipid monolayer. This prediction is validated by experimental recordings with the Brandaris camera, operated at several million frames per second. The effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles, is predicted by the model. Further, the model corrects a flaw in the shell elasticity term previously used in the dynamical equation for coated bubbles. The break-up ismodeled by a critical shell tension above which gas is directly exposed to water.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Lohse, Detlef , Supervisor
  • de Jong, Nico, Supervisor
  • Versluis, Michel, Co-Supervisor
Award date13 Sep 2007
Publisher
Print ISBNs978-90-365-2548-0
Publication statusPublished - 13 Sep 2007

Fingerprint

bubbles
buckling
pressure pulses
high speed cameras
theses
compressibility
lipids
elastic properties
physical properties
recording
cameras
coatings
oscillations
radii
acoustics
defects
predictions
gases
water

Keywords

  • IR-57925

Cite this

van der Meer, S. M. (2007). Ultrasound contrast agents: resonances of coated bubbles. University of Twente.
van der Meer, Sander Martijn. / Ultrasound contrast agents : resonances of coated bubbles. University of Twente, 2007. 149 p.
@phdthesis{442e6bf61bbe4e04a5f70ef3525da0ce,
title = "Ultrasound contrast agents: resonances of coated bubbles",
abstract = "The Brandaris 128 high speed camera was designed and built in order to analyze the dynamics of single oscillating contrast agent microbubbles under influence of ultrasound. In this thesis we report on our findings. First, in Ch. 2, a new model was introduced which takes into account the physical properties of a lipidmonolayer coating on a gasmicrobubble. Three parameters describe the properties of the shell: a buckling radius, the compressibility of the shell, and a break-up shell tension. The model presents an original non-linear behavior at large amplitude oscillations, termed compression–only, induced by the buckling of the lipid monolayer. This prediction is validated by experimental recordings with the Brandaris camera, operated at several million frames per second. The effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles, is predicted by the model. Further, the model corrects a flaw in the shell elasticity term previously used in the dynamical equation for coated bubbles. The break-up ismodeled by a critical shell tension above which gas is directly exposed to water.",
keywords = "IR-57925",
author = "{van der Meer}, {Sander Martijn}",
year = "2007",
month = "9",
day = "13",
language = "English",
isbn = "978-90-365-2548-0",
publisher = "University of Twente",
address = "Netherlands",
school = "University of Twente",

}

van der Meer, SM 2007, 'Ultrasound contrast agents: resonances of coated bubbles', University of Twente.

Ultrasound contrast agents : resonances of coated bubbles. / van der Meer, Sander Martijn.

University of Twente, 2007. 149 p.

Research output: ThesisPhD Thesis - Research UT, graduation UTAcademic

TY - THES

T1 - Ultrasound contrast agents

T2 - resonances of coated bubbles

AU - van der Meer, Sander Martijn

PY - 2007/9/13

Y1 - 2007/9/13

N2 - The Brandaris 128 high speed camera was designed and built in order to analyze the dynamics of single oscillating contrast agent microbubbles under influence of ultrasound. In this thesis we report on our findings. First, in Ch. 2, a new model was introduced which takes into account the physical properties of a lipidmonolayer coating on a gasmicrobubble. Three parameters describe the properties of the shell: a buckling radius, the compressibility of the shell, and a break-up shell tension. The model presents an original non-linear behavior at large amplitude oscillations, termed compression–only, induced by the buckling of the lipid monolayer. This prediction is validated by experimental recordings with the Brandaris camera, operated at several million frames per second. The effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles, is predicted by the model. Further, the model corrects a flaw in the shell elasticity term previously used in the dynamical equation for coated bubbles. The break-up ismodeled by a critical shell tension above which gas is directly exposed to water.

AB - The Brandaris 128 high speed camera was designed and built in order to analyze the dynamics of single oscillating contrast agent microbubbles under influence of ultrasound. In this thesis we report on our findings. First, in Ch. 2, a new model was introduced which takes into account the physical properties of a lipidmonolayer coating on a gasmicrobubble. Three parameters describe the properties of the shell: a buckling radius, the compressibility of the shell, and a break-up shell tension. The model presents an original non-linear behavior at large amplitude oscillations, termed compression–only, induced by the buckling of the lipid monolayer. This prediction is validated by experimental recordings with the Brandaris camera, operated at several million frames per second. The effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles, is predicted by the model. Further, the model corrects a flaw in the shell elasticity term previously used in the dynamical equation for coated bubbles. The break-up ismodeled by a critical shell tension above which gas is directly exposed to water.

KW - IR-57925

M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-2548-0

PB - University of Twente

ER -

van der Meer SM. Ultrasound contrast agents: resonances of coated bubbles. University of Twente, 2007. 149 p.