Ultrasound-induced Gas Release from Contrast Agent Microbubbles

M.A.B. Postema, Michiel Postema, Ayache Bouakaz, Michel Versluis, N. de Jong

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We investigated gas release from two hard-shelled ultrasound contrast agents by subjecting them to high-mechanical index (MI) ultrasound and simultaneously capturing high-speed photographs. At an insonifying frequency of 1.7 MHz, a larger percentage of contrast bubbles is seen to crack than at 0.5 MHz. Most of the released gas bubbles have equilibrium diameters between 1.25 and 1.75 /spl mu/m. Their disappearance was observed optically. Free gas bubbles have equilibrium diameters smaller than the bubbles from which they have been released. Coalescence may account for the long dissolution times acoustically observed and published in previous studies. After sonic cracking, the cracked bubbles stay acoustically active.
Original languageUndefined
Pages (from-to)1035-1041
Number of pages7
JournalIEEE transactions on ultrasonics, ferroelectrics and frequency control
Issue number6
Publication statusPublished - 2005


  • METIS-228144
  • IR-54288

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