Ultrasound-induced Gas Release from Contrast Agent Microbubbles

M.A.B. Postema; Michiel Postema; Ayache Bouakaz; Michel Versluis; N. de Jong

doi:10.1109/TUFFC.2005.1504026

Ultrasound-induced Gas Release from Contrast Agent Microbubbles

M.A.B. Postema, Michiel Postema, Ayache Bouakaz, Michel Versluis, N. de Jong

Research output: Contribution to journal › Article › Academic › peer-review

65 Citations (Scopus)

164 Downloads (Pure)

Abstract

We investigated gas release from two hard-shelled ultrasound contrast agents by subjecting them to high-mechanical index (MI) ultrasound and simultaneously capturing high-speed photographs. At an insonifying frequency of 1.7 MHz, a larger percentage of contrast bubbles is seen to crack than at 0.5 MHz. Most of the released gas bubbles have equilibrium diameters between 1.25 and 1.75 /spl mu/m. Their disappearance was observed optically. Free gas bubbles have equilibrium diameters smaller than the bubbles from which they have been released. Coalescence may account for the long dissolution times acoustically observed and published in previous studies. After sonic cracking, the cracked bubbles stay acoustically active.

Original language	Undefined
Pages (from-to)	1035-1041
Number of pages	7
Journal	IEEE transactions on ultrasonics, ferroelectrics and frequency control
Volume	52
Issue number	6
DOIs	https://doi.org/10.1109/TUFFC.2005.1504026
Publication status	Published - 2005

Keywords

METIS-228144
IR-54288

Access to Document

10.1109/TUFFC.2005.1504026

01504026

Cite this

@article{ad09be68721c4740a56863a3f0c24c71,

title = "Ultrasound-induced Gas Release from Contrast Agent Microbubbles",

abstract = "We investigated gas release from two hard-shelled ultrasound contrast agents by subjecting them to high-mechanical index (MI) ultrasound and simultaneously capturing high-speed photographs. At an insonifying frequency of 1.7 MHz, a larger percentage of contrast bubbles is seen to crack than at 0.5 MHz. Most of the released gas bubbles have equilibrium diameters between 1.25 and 1.75 /spl mu/m. Their disappearance was observed optically. Free gas bubbles have equilibrium diameters smaller than the bubbles from which they have been released. Coalescence may account for the long dissolution times acoustically observed and published in previous studies. After sonic cracking, the cracked bubbles stay acoustically active.",

keywords = "METIS-228144, IR-54288",

author = "M.A.B. Postema and Michiel Postema and Ayache Bouakaz and Michel Versluis and {de Jong}, N.",

year = "2005",

doi = "10.1109/TUFFC.2005.1504026",

language = "Undefined",

volume = "52",

pages = "1035--1041",

journal = "IEEE transactions on ultrasonics, ferroelectrics and frequency control",

issn = "0885-3010",

publisher = "IEEE",

number = "6",

}

TY - JOUR

T1 - Ultrasound-induced Gas Release from Contrast Agent Microbubbles

AU - Postema, M.A.B.

AU - Postema, Michiel

AU - Bouakaz, Ayache

AU - Versluis, Michel

AU - de Jong, N.

PY - 2005

Y1 - 2005

N2 - We investigated gas release from two hard-shelled ultrasound contrast agents by subjecting them to high-mechanical index (MI) ultrasound and simultaneously capturing high-speed photographs. At an insonifying frequency of 1.7 MHz, a larger percentage of contrast bubbles is seen to crack than at 0.5 MHz. Most of the released gas bubbles have equilibrium diameters between 1.25 and 1.75 /spl mu/m. Their disappearance was observed optically. Free gas bubbles have equilibrium diameters smaller than the bubbles from which they have been released. Coalescence may account for the long dissolution times acoustically observed and published in previous studies. After sonic cracking, the cracked bubbles stay acoustically active.

AB - We investigated gas release from two hard-shelled ultrasound contrast agents by subjecting them to high-mechanical index (MI) ultrasound and simultaneously capturing high-speed photographs. At an insonifying frequency of 1.7 MHz, a larger percentage of contrast bubbles is seen to crack than at 0.5 MHz. Most of the released gas bubbles have equilibrium diameters between 1.25 and 1.75 /spl mu/m. Their disappearance was observed optically. Free gas bubbles have equilibrium diameters smaller than the bubbles from which they have been released. Coalescence may account for the long dissolution times acoustically observed and published in previous studies. After sonic cracking, the cracked bubbles stay acoustically active.

KW - METIS-228144

KW - IR-54288

U2 - 10.1109/TUFFC.2005.1504026

DO - 10.1109/TUFFC.2005.1504026

M3 - Article

VL - 52

SP - 1035

EP - 1041

JO - IEEE transactions on ultrasonics, ferroelectrics and frequency control

JF - IEEE transactions on ultrasonics, ferroelectrics and frequency control

SN - 0885-3010

IS - 6

ER -