TY - JOUR
T1 - Ultrasound-mediated drug delivery to the brain: principles, progress and prospects
AU - Dasgupta, I.
AU - Liu, M.
AU - Ojha, T.
AU - Storm, Gerrit
AU - Kiessling, F.
AU - Lammers, Twan Gerardus Gertudis Maria
PY - 2016
Y1 - 2016
N2 - The blood–brain barrier (BBB) limits drug delivery to the central nervous system. When combined with microbubbles, ultrasound can transiently permeate blood vessels in the brain. This approach, which can be referred to as sonoporation or sonopermeabilization, holds significant promise for shuttling large therapeutic molecules, such as antibodies, growth factors and nanomedicine formulations, across the BBB. We here describe the basic principles of BBB permeation using ultrasound and microbubbles, and we summarize several (pre-) clinical studies showing the potential of BBB opening for improving the treatment of cancer and neurodegenerative disorders
AB - The blood–brain barrier (BBB) limits drug delivery to the central nervous system. When combined with microbubbles, ultrasound can transiently permeate blood vessels in the brain. This approach, which can be referred to as sonoporation or sonopermeabilization, holds significant promise for shuttling large therapeutic molecules, such as antibodies, growth factors and nanomedicine formulations, across the BBB. We here describe the basic principles of BBB permeation using ultrasound and microbubbles, and we summarize several (pre-) clinical studies showing the potential of BBB opening for improving the treatment of cancer and neurodegenerative disorders
KW - METIS-320801
KW - IR-103530
U2 - 10.1016/j.ddtec.2016.07.007
DO - 10.1016/j.ddtec.2016.07.007
M3 - Article
VL - 20
SP - 41
EP - 48
JO - Drug discovery today
JF - Drug discovery today
SN - 1359-6446
ER -