Ultrasound-mediated drug delivery to the brain: principles, progress and prospects

Anshuman Dasgupta; Mengjiao Liu; Tarun Ojha; Gert Storm; Fabian Kiessling; Twan Lammers

doi:10.1016/j.ddtec.2016.07.007

Ultrasound-mediated drug delivery to the brain: principles, progress and prospects

Anshuman Dasgupta
, Mengjiao Liu
, Tarun Ojha
, Gert Storm
, Fabian Kiessling
, Twan Lammers^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

143 Citations (Scopus)

151 Downloads (Pure)

Abstract

The blood–brain barrier (BBB) limits drug delivery to the central nervous system. When combined with microbubbles, ultrasound can transiently permeate blood vessels in the brain. This approach, which can be referred to as sonoporation or sonopermeabilization, holds significant promise for shuttling large therapeutic molecules, such as antibodies, growth factors and nanomedicine formulations, across the BBB. We here describe the basic principles of BBB permeation using ultrasound and microbubbles, and we summarize several (pre-) clinical studies showing the potential of BBB opening for improving the treatment of cancer and neurodegenerative disorders.

Original language	English
Pages (from-to)	41-48
Number of pages	8
Journal	Drug Discovery Today: Technologies
Volume	20
DOIs	https://doi.org/10.1016/j.ddtec.2016.07.007
Publication status	Published - 1 Jun 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

2023 OA procedure

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10.1016/j.ddtec.2016.07.007

ArticleFinal published version, 1.18 MBLicence: Taverne

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AU - Dasgupta, Anshuman

AU - Liu, Mengjiao

AU - Ojha, Tarun

AU - Storm, Gert

AU - Kiessling, Fabian

AU - Lammers, Twan

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The blood–brain barrier (BBB) limits drug delivery to the central nervous system. When combined with microbubbles, ultrasound can transiently permeate blood vessels in the brain. This approach, which can be referred to as sonoporation or sonopermeabilization, holds significant promise for shuttling large therapeutic molecules, such as antibodies, growth factors and nanomedicine formulations, across the BBB. We here describe the basic principles of BBB permeation using ultrasound and microbubbles, and we summarize several (pre-) clinical studies showing the potential of BBB opening for improving the treatment of cancer and neurodegenerative disorders.

AB - The blood–brain barrier (BBB) limits drug delivery to the central nervous system. When combined with microbubbles, ultrasound can transiently permeate blood vessels in the brain. This approach, which can be referred to as sonoporation or sonopermeabilization, holds significant promise for shuttling large therapeutic molecules, such as antibodies, growth factors and nanomedicine formulations, across the BBB. We here describe the basic principles of BBB permeation using ultrasound and microbubbles, and we summarize several (pre-) clinical studies showing the potential of BBB opening for improving the treatment of cancer and neurodegenerative disorders.

KW - 2023 OA procedure

UR - https://www.scopus.com/pages/publications/85002913087

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DO - 10.1016/j.ddtec.2016.07.007

M3 - Review article

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SP - 41

EP - 48

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

ER -

Ultrasound-mediated drug delivery to the brain: principles, progress and prospects

Abstract

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