TY - JOUR
T1 - Ultrasound-mediated targeted microbubble sonoporation of endothelial cells
AU - Kooiman, Klazina
AU - Foppen-Harteveld, Miranda
AU - de Jong, N.
PY - 2010
Y1 - 2010
N2 - Molecular imaging using ultrasound makes use of targeted microbubbles. In this study we investigated whether these microbubbles could also be used to induce drug uptake in endothelial cells. CD31-targeted microbubbles insonified at 1 MHz induced sonoporation when they were larger than 3.0 μm or when their relative vibration amplitude was larger than 0.5. No relationship was found between the position of the microbubble on the cell and the induction of sonoporation.
AB - Molecular imaging using ultrasound makes use of targeted microbubbles. In this study we investigated whether these microbubbles could also be used to induce drug uptake in endothelial cells. CD31-targeted microbubbles insonified at 1 MHz induced sonoporation when they were larger than 3.0 μm or when their relative vibration amplitude was larger than 0.5. No relationship was found between the position of the microbubble on the cell and the induction of sonoporation.
KW - IR-80271
U2 - 10.1016/j.jconrel.2010.07.025
DO - 10.1016/j.jconrel.2010.07.025
M3 - Article
VL - 148
SP - e62-e63
JO - Journal of controlled release
JF - Journal of controlled release
SN - 0168-3659
IS - 1
ER -