Ultrasound microbubble induced endothelial cell permeability

A. van Wamel; K. Kooiman; M. Emmer; F.J. ten Cate; Michel Versluis; N. de Jong

doi:10.1016/j.jconrel.2006.09.071

Ultrasound microbubble induced endothelial cell permeability

A. van Wamel, K. Kooiman, M. Emmer, F.J. ten Cate, Michel Versluis, N. de Jong

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Abstract

Ultrasound microbubbles have the ability to enhance cell permeability that can be used to deliver drugs intervascular through the transfer of extracellular molecules into cells. The present study is designed to correlate the relationship between microbubble induced cell deformation and enhanced cell membrane permeability. Using high-speed imaging of vibrating microbubbles against endothelial cells and imaging transport of propidium iodide into these cells showed a direct correlation between cell deformation and resulting cell membrane permeability.

Original language	Undefined
Pages (from-to)	e100-e102
Journal	Journal of controlled release
Volume	116
Issue number	2
DOIs	https://doi.org/10.1016/j.jconrel.2006.09.071
Publication status	Published - 2006

Keywords

IR-78556

Access to Document

10.1016/j.jconrel.2006.09.071

Cite this

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title = "Ultrasound microbubble induced endothelial cell permeability",

abstract = "Ultrasound microbubbles have the ability to enhance cell permeability that can be used to deliver drugs intervascular through the transfer of extracellular molecules into cells. The present study is designed to correlate the relationship between microbubble induced cell deformation and enhanced cell membrane permeability. Using high-speed imaging of vibrating microbubbles against endothelial cells and imaging transport of propidium iodide into these cells showed a direct correlation between cell deformation and resulting cell membrane permeability.",

keywords = "IR-78556",

author = "{van Wamel}, A. and K. Kooiman and M. Emmer and {ten Cate}, F.J. and Michel Versluis and {de Jong}, N.",

year = "2006",

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language = "Undefined",

volume = "116",

pages = "e100--e102",

journal = "Journal of controlled release",

issn = "0168-3659",

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T1 - Ultrasound microbubble induced endothelial cell permeability

AU - van Wamel, A.

AU - Kooiman, K.

AU - Emmer, M.

AU - ten Cate, F.J.

AU - Versluis, Michel

AU - de Jong, N.

PY - 2006

Y1 - 2006

N2 - Ultrasound microbubbles have the ability to enhance cell permeability that can be used to deliver drugs intervascular through the transfer of extracellular molecules into cells. The present study is designed to correlate the relationship between microbubble induced cell deformation and enhanced cell membrane permeability. Using high-speed imaging of vibrating microbubbles against endothelial cells and imaging transport of propidium iodide into these cells showed a direct correlation between cell deformation and resulting cell membrane permeability.

AB - Ultrasound microbubbles have the ability to enhance cell permeability that can be used to deliver drugs intervascular through the transfer of extracellular molecules into cells. The present study is designed to correlate the relationship between microbubble induced cell deformation and enhanced cell membrane permeability. Using high-speed imaging of vibrating microbubbles against endothelial cells and imaging transport of propidium iodide into these cells showed a direct correlation between cell deformation and resulting cell membrane permeability.

KW - IR-78556

U2 - 10.1016/j.jconrel.2006.09.071

DO - 10.1016/j.jconrel.2006.09.071

M3 - Article

SN - 0168-3659

VL - 116

SP - e100-e102

JO - Journal of controlled release

JF - Journal of controlled release

IS - 2

ER -