Ultrasound therapy with drug loaded microcapsules

William T. Shi, Marcel Böhmer, Annemieke van Wamel, Muzaffer Celebi, Alexander L. Klibanov, Chien Ting Chin, Ceciel Chlon, Marcia Emmer, Klazina Kooiman, Nico de Jong, Christopher S. Hall

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

12 Citations (Scopus)


A novel class of acoustically active microcapsules that partially contain drug-bearing oil with gas offers great potential for localized drug release. The acoustical activation threshold and rate of such microcapsules with different oil-to-gas ratios were measured in vitro. Drug loaded microcapsules were prepared from which the anti-cancer drug paclitaxel was delivered in murine tumors. For recovered mice each with two tumors on the left and right hind legs, the growth rate of the acoustically treated tumors was substantially reduced in comparison to that of the untreated tumor on the same mouse. These initial results showed that lipophilic drugs can be packaged in microcapsules and released locally using focused ultrasound.
Original languageEnglish
Title of host publication2007 IEEE Ultrasonics Symposium Proceedings
Place of PublicationPiscataway, NJ
Number of pages4
ISBN (Print)978-1-4244-1383-6, 978-1-4244-1384-3 (CD)
Publication statusPublished - 28 Oct 2007
Externally publishedYes
EventIEEE International Ultrasonics Symposium 2007 - New York, United States
Duration: 28 Oct 200731 Oct 2007

Publication series

NameIEEE Ultrasonics Symposium Proceedings
ISSN (Print)1051-0117


ConferenceIEEE International Ultrasonics Symposium 2007
Country/TerritoryUnited States
CityNew York


  • n/a OA procedure


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