A bioinformatician has a large number of homology data sources to choose from. These data sources need to be combined before a query can be posed over the combined data. We propose a generic probabilistic approach to combining grouping data from multiple sources. Our approach incorporates an iteratively evolving view on trust, allowing the bioinformatician to express his fine-grained view on how much the data in the sources can be trusted. We evaluate our approach by combining 3 real-world biological databases and show that it scales well for realistic amounts of data and uncertainty.
|Place of Publication||Enschede|
|Publisher||Centre for Telematics and Information Technology (CTIT)|
|Number of pages||10|
|Publication status||Published - 5 Dec 2014|
|Name||CTIT Technical Report Series|
|Publisher||University of Twente, Centre for Telematics and Information Technology (CTIT)|
Wanders, B., van Keulen, M., & van der Vet, P. E. (2014). Uncertain groupings: probabilistic combination of grouping data. (CTIT Technical Report Series; No. TR-CTIT-14-12). Enschede: Centre for Telematics and Information Technology (CTIT).