Understanding the complexity of cardiogenic shock management: the added value of advanced computational modeling

Christiaan L. Meuwese, Lex M. van Loon, Dirk W. Donker*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Purpose of review The purpose of this review is to explain the value of computational physiological modeling for in-depth understanding of the complex derangements of cardiopulmonary pathophysiology during cardiogenic shock, particularly when treated with temporary mechanical circulatory support (tMCS) devices. Recent findings Computational physiological models have evolved in recent years and can provide a high degree of clinical realism in the simulation of cardiogenic shock and related conservative and interventional therapies. These models feature a large spectrum of practically relevant hemodynamic and respiratory parameters tunable to patient-specific disease states as well as adjustable to medical therapies and support device settings. Current applications work in real-time and can operate on an ordinary computer, laptop or mobile device. Summary The use of computational physiological models is increasingly appreciated for educational purposes as they help to understand the complexity of cardiogenic shock, especially when sophisticated management of tMCS is involved in addition to multimodal critical care support. Practical implementation of computational models as clinical decision support tools at the bedside is at the horizon but awaits rigorous clinical validation.

Original languageEnglish
Pages (from-to)340-343
Number of pages4
JournalCurrent Opinion in Critical Care
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Aug 2024

Keywords

  • 2024 OA procedure
  • computational physiological modeling
  • critical care
  • education
  • ICU
  • Impella
  • micro-axial pump
  • simulation
  • temporary mechanical circulatory support
  • venoarterial extracorporeal membrane oxygenation
  • cardiogenic shock

Fingerprint

Dive into the research topics of 'Understanding the complexity of cardiogenic shock management: the added value of advanced computational modeling'. Together they form a unique fingerprint.

Cite this