Unified Huntington's disease rating scale: A follow up

Sabine Siesling, Jeroen P.P. van Vugt, Koos A.H. Zwinderman, Karl Kieburtz, Raymund A.C. Roos

Research output: Contribution to journalArticleAcademicpeer-review

86 Citations (Scopus)

Abstract

An objective assessment of the clinical findings in patients with Huntington's disease (HD) is necessary for an evaluation of the longitudinal progression of the disease features. The Unified Huntington's Disease Rating Scale (UHDRS) is a scale to assess clinical performance and functional capacity. The authors examined the 1-year change in UHDRS scores in 78 patients with HD examined either in Leiden, the Netherlands (24 men, 25 women), or in Rochester, New York, United States (12 men, 17 women). A significant decline was seen in motor function, measured with the total motor scale. The total dystonia score increased significantly; the total chorea score did not. The frequency of behavioral disorders tended to increase. The scores on independence scale, functional assessment, total functional capacity, and symbol digit decreased significantly. No relation was observed between the UHDRS items and the age at onset or duration of illness. Thirteen patients with 2-year follow up showed a clear increase in score on the total motor scale and a decline on the independence scale and in total functional capacity. The UHDRS may also be used as a tool for determining therapeutic intervention. Annual evaluation of the total motor scale in every patient gives a clear description of the motor progression of the disease. The authors suggest performing a total UHDRS evaluation every second year for every HD patient as part of the routine longitudinal evaluation.

Original languageEnglish
Pages (from-to)915-919
Number of pages5
JournalMovement disorders
Volume13
Issue number6
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

Fingerprint

Huntington Disease
Disease Progression
Chorea
Dystonia
Age of Onset
Netherlands

Keywords

  • Huntington's disease
  • Longitudinal assessment
  • UHDRS

Cite this

Siesling, S., van Vugt, J. P. P., Zwinderman, K. A. H., Kieburtz, K., & Roos, R. A. C. (1998). Unified Huntington's disease rating scale: A follow up. Movement disorders, 13(6), 915-919. https://doi.org/10.1002/mds.870130609
Siesling, Sabine ; van Vugt, Jeroen P.P. ; Zwinderman, Koos A.H. ; Kieburtz, Karl ; Roos, Raymund A.C. / Unified Huntington's disease rating scale : A follow up. In: Movement disorders. 1998 ; Vol. 13, No. 6. pp. 915-919.
@article{0f6b58eae8654ca0a7db1cf03cc5d458,
title = "Unified Huntington's disease rating scale: A follow up",
abstract = "An objective assessment of the clinical findings in patients with Huntington's disease (HD) is necessary for an evaluation of the longitudinal progression of the disease features. The Unified Huntington's Disease Rating Scale (UHDRS) is a scale to assess clinical performance and functional capacity. The authors examined the 1-year change in UHDRS scores in 78 patients with HD examined either in Leiden, the Netherlands (24 men, 25 women), or in Rochester, New York, United States (12 men, 17 women). A significant decline was seen in motor function, measured with the total motor scale. The total dystonia score increased significantly; the total chorea score did not. The frequency of behavioral disorders tended to increase. The scores on independence scale, functional assessment, total functional capacity, and symbol digit decreased significantly. No relation was observed between the UHDRS items and the age at onset or duration of illness. Thirteen patients with 2-year follow up showed a clear increase in score on the total motor scale and a decline on the independence scale and in total functional capacity. The UHDRS may also be used as a tool for determining therapeutic intervention. Annual evaluation of the total motor scale in every patient gives a clear description of the motor progression of the disease. The authors suggest performing a total UHDRS evaluation every second year for every HD patient as part of the routine longitudinal evaluation.",
keywords = "Huntington's disease, Longitudinal assessment, UHDRS",
author = "Sabine Siesling and {van Vugt}, {Jeroen P.P.} and Zwinderman, {Koos A.H.} and Karl Kieburtz and Roos, {Raymund A.C.}",
year = "1998",
month = "1",
day = "1",
doi = "10.1002/mds.870130609",
language = "English",
volume = "13",
pages = "915--919",
journal = "Movement disorders",
issn = "0885-3185",
publisher = "Wiley",
number = "6",

}

Siesling, S, van Vugt, JPP, Zwinderman, KAH, Kieburtz, K & Roos, RAC 1998, 'Unified Huntington's disease rating scale: A follow up' Movement disorders, vol. 13, no. 6, pp. 915-919. https://doi.org/10.1002/mds.870130609

Unified Huntington's disease rating scale : A follow up. / Siesling, Sabine; van Vugt, Jeroen P.P.; Zwinderman, Koos A.H.; Kieburtz, Karl; Roos, Raymund A.C.

In: Movement disorders, Vol. 13, No. 6, 01.01.1998, p. 915-919.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Unified Huntington's disease rating scale

T2 - A follow up

AU - Siesling, Sabine

AU - van Vugt, Jeroen P.P.

AU - Zwinderman, Koos A.H.

AU - Kieburtz, Karl

AU - Roos, Raymund A.C.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - An objective assessment of the clinical findings in patients with Huntington's disease (HD) is necessary for an evaluation of the longitudinal progression of the disease features. The Unified Huntington's Disease Rating Scale (UHDRS) is a scale to assess clinical performance and functional capacity. The authors examined the 1-year change in UHDRS scores in 78 patients with HD examined either in Leiden, the Netherlands (24 men, 25 women), or in Rochester, New York, United States (12 men, 17 women). A significant decline was seen in motor function, measured with the total motor scale. The total dystonia score increased significantly; the total chorea score did not. The frequency of behavioral disorders tended to increase. The scores on independence scale, functional assessment, total functional capacity, and symbol digit decreased significantly. No relation was observed between the UHDRS items and the age at onset or duration of illness. Thirteen patients with 2-year follow up showed a clear increase in score on the total motor scale and a decline on the independence scale and in total functional capacity. The UHDRS may also be used as a tool for determining therapeutic intervention. Annual evaluation of the total motor scale in every patient gives a clear description of the motor progression of the disease. The authors suggest performing a total UHDRS evaluation every second year for every HD patient as part of the routine longitudinal evaluation.

AB - An objective assessment of the clinical findings in patients with Huntington's disease (HD) is necessary for an evaluation of the longitudinal progression of the disease features. The Unified Huntington's Disease Rating Scale (UHDRS) is a scale to assess clinical performance and functional capacity. The authors examined the 1-year change in UHDRS scores in 78 patients with HD examined either in Leiden, the Netherlands (24 men, 25 women), or in Rochester, New York, United States (12 men, 17 women). A significant decline was seen in motor function, measured with the total motor scale. The total dystonia score increased significantly; the total chorea score did not. The frequency of behavioral disorders tended to increase. The scores on independence scale, functional assessment, total functional capacity, and symbol digit decreased significantly. No relation was observed between the UHDRS items and the age at onset or duration of illness. Thirteen patients with 2-year follow up showed a clear increase in score on the total motor scale and a decline on the independence scale and in total functional capacity. The UHDRS may also be used as a tool for determining therapeutic intervention. Annual evaluation of the total motor scale in every patient gives a clear description of the motor progression of the disease. The authors suggest performing a total UHDRS evaluation every second year for every HD patient as part of the routine longitudinal evaluation.

KW - Huntington's disease

KW - Longitudinal assessment

KW - UHDRS

UR - http://www.scopus.com/inward/record.url?scp=0031740575&partnerID=8YFLogxK

U2 - 10.1002/mds.870130609

DO - 10.1002/mds.870130609

M3 - Article

VL - 13

SP - 915

EP - 919

JO - Movement disorders

JF - Movement disorders

SN - 0885-3185

IS - 6

ER -

Siesling S, van Vugt JPP, Zwinderman KAH, Kieburtz K, Roos RAC. Unified Huntington's disease rating scale: A follow up. Movement disorders. 1998 Jan 1;13(6):915-919. https://doi.org/10.1002/mds.870130609