Universal Equations for the Coalescence Probability and Long-Term Size Stability of Phospholipid-Coated Monodisperse Microbubbles Formed by Flow Focusing

Tim Segers, Detlef Lohse, Michel Versluis, Peter J.A. Frinking

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Resonantly driven monodisperse phospholipid-coated microbubbles are expected to substantially increase the sensitivity and efficiency in contrast-enhanced ultrasound imaging and therapy. They can be produced in a microfluidic flow-focusing device, but questions remain as to the role of the device geometry, the liquid and gas flow, and the phospholipid formulation on bubble stability. Here, we develop a model based on simple continuum mechanics equations that reveals the scaling of the coalescence probability with the key physical parameters. It is used to characterize short-term coalescence behavior and long-term size stability as a function of flow-focusing geometry, bulk viscosity, lipid cosolvent mass fraction, lipid concentration, lipopolymer molecular weight, and lipopolymer molar fraction. All collected data collapse on two master curves given by universal equations for the coalescence probability and the long-term size stability. This work is therefore a route to a more fundamental understanding of the physicochemical monolayer properties of microfluidically formed bubbles and their coalescence behavior in a flow-focusing device.

Original languageEnglish
Pages (from-to)10329-10339
Number of pages11
JournalLangmuir
Volume33
Issue number39
DOIs
Publication statusPublished - 3 Oct 2017

Fingerprint

Phospholipids
Coalescence
coalescing
Lipids
lipids
bubbles
continuum mechanics
Continuum mechanics
Geometry
liquid flow
geometry
Microfluidics
gas flow
Flow of gases
Monolayers
therapy
molecular weight
Ultrasonics
Molecular weight
routes

Cite this

@article{fae7f190e85045a597ca101bcbcaecdd,
title = "Universal Equations for the Coalescence Probability and Long-Term Size Stability of Phospholipid-Coated Monodisperse Microbubbles Formed by Flow Focusing",
abstract = "Resonantly driven monodisperse phospholipid-coated microbubbles are expected to substantially increase the sensitivity and efficiency in contrast-enhanced ultrasound imaging and therapy. They can be produced in a microfluidic flow-focusing device, but questions remain as to the role of the device geometry, the liquid and gas flow, and the phospholipid formulation on bubble stability. Here, we develop a model based on simple continuum mechanics equations that reveals the scaling of the coalescence probability with the key physical parameters. It is used to characterize short-term coalescence behavior and long-term size stability as a function of flow-focusing geometry, bulk viscosity, lipid cosolvent mass fraction, lipid concentration, lipopolymer molecular weight, and lipopolymer molar fraction. All collected data collapse on two master curves given by universal equations for the coalescence probability and the long-term size stability. This work is therefore a route to a more fundamental understanding of the physicochemical monolayer properties of microfluidically formed bubbles and their coalescence behavior in a flow-focusing device.",
author = "Tim Segers and Detlef Lohse and Michel Versluis and Frinking, {Peter J.A.}",
year = "2017",
month = "10",
day = "3",
doi = "10.1021/acs.langmuir.7b02547",
language = "English",
volume = "33",
pages = "10329--10339",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "39",

}

Universal Equations for the Coalescence Probability and Long-Term Size Stability of Phospholipid-Coated Monodisperse Microbubbles Formed by Flow Focusing. / Segers, Tim; Lohse, Detlef; Versluis, Michel; Frinking, Peter J.A.

In: Langmuir, Vol. 33, No. 39, 03.10.2017, p. 10329-10339.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Universal Equations for the Coalescence Probability and Long-Term Size Stability of Phospholipid-Coated Monodisperse Microbubbles Formed by Flow Focusing

AU - Segers, Tim

AU - Lohse, Detlef

AU - Versluis, Michel

AU - Frinking, Peter J.A.

PY - 2017/10/3

Y1 - 2017/10/3

N2 - Resonantly driven monodisperse phospholipid-coated microbubbles are expected to substantially increase the sensitivity and efficiency in contrast-enhanced ultrasound imaging and therapy. They can be produced in a microfluidic flow-focusing device, but questions remain as to the role of the device geometry, the liquid and gas flow, and the phospholipid formulation on bubble stability. Here, we develop a model based on simple continuum mechanics equations that reveals the scaling of the coalescence probability with the key physical parameters. It is used to characterize short-term coalescence behavior and long-term size stability as a function of flow-focusing geometry, bulk viscosity, lipid cosolvent mass fraction, lipid concentration, lipopolymer molecular weight, and lipopolymer molar fraction. All collected data collapse on two master curves given by universal equations for the coalescence probability and the long-term size stability. This work is therefore a route to a more fundamental understanding of the physicochemical monolayer properties of microfluidically formed bubbles and their coalescence behavior in a flow-focusing device.

AB - Resonantly driven monodisperse phospholipid-coated microbubbles are expected to substantially increase the sensitivity and efficiency in contrast-enhanced ultrasound imaging and therapy. They can be produced in a microfluidic flow-focusing device, but questions remain as to the role of the device geometry, the liquid and gas flow, and the phospholipid formulation on bubble stability. Here, we develop a model based on simple continuum mechanics equations that reveals the scaling of the coalescence probability with the key physical parameters. It is used to characterize short-term coalescence behavior and long-term size stability as a function of flow-focusing geometry, bulk viscosity, lipid cosolvent mass fraction, lipid concentration, lipopolymer molecular weight, and lipopolymer molar fraction. All collected data collapse on two master curves given by universal equations for the coalescence probability and the long-term size stability. This work is therefore a route to a more fundamental understanding of the physicochemical monolayer properties of microfluidically formed bubbles and their coalescence behavior in a flow-focusing device.

UR - http://www.scopus.com/inward/record.url?scp=85030681430&partnerID=8YFLogxK

U2 - 10.1021/acs.langmuir.7b02547

DO - 10.1021/acs.langmuir.7b02547

M3 - Article

VL - 33

SP - 10329

EP - 10339

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 39

ER -