Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis

H. J. Albers*, J. E.A. Linssen, P. F. Costa, H. H.T. Middelkamp, L. van der Hout, J. Malda, R. Passier, A. van den Berg, A. D. van der Meer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

Abstract

Vascular microfluidic models were manufactured using stereolithography and soft lithography based on computed tomography angiography data. These microfluidic chips were lined with endothelial cells and the devices could be perfused with human whole blood at arterial shear rates. When comparing healthy and stenotic geometries the healthy geometries showed no sign of platelet aggregation, while stenotic geometries showed platelet aggregation near and distal of the stenotic apex.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherThe Chemical and Biological Microsystems Society
Pages1070-1071
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 1 Jan 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21
https://www.microtas2017.org/

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017
Abbreviated titleMicroTAS
CountryUnited States
CitySavannah
Period22/10/1726/10/17
Internet address

Keywords

  • 3D-printing
  • Arterial
  • Organ-on-chip
  • SLA
  • Thrombosis
  • Vasculature

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